Publikationer pr. år
Publikationer pr. år
Personlig profil
Forskningsprofil
The research of Peter Kristensen is centered on the technical development and application of methods that allow Darwinian evolution of proteins using directed evolution technologies.
The main scientific contributions have more specifically been in the area of recombinant antibodies and methods of isolating such antibodies from large libraries. In addition Peter Kristensen was the first to develop technologies which allow isolation of proteins with improved stabilities from large libraries of mutants. The interest to make technological developments based on recombinant antibodies and for manipulating protein stability and activity, were initiated while Peter Kristensen performed his post doc at the MRC-LMB in Cambridge in the group of Nobel Laureate Sir Greg Winter. However to justify technological development, the technology developed should be able to provide new insight or solve important problems and here we have especially focused attention at finding novel biomarkers which can be used in characterization of important human conditions, such as age related diseases and rare circulating cells in the blood, just to mention the most relevant example. Most recently, the research has involved the use of non-natural amino acids for immobilization and conjugation of recombinant antibodies and proteins of industrial interest and novel biosensors building on recombinant antibody technology.
Ph.d.-vejledning
|
Name |
Title of Thesis |
University of Enrolment |
Year |
Role |
|
Svend Kjær |
Use of phage displayed repertoires in the study of eukaryotic elongation factor 1A |
Aarhus University |
1998 |
Project Supervisor |
|
Henrik Sølvsten |
Detection and Regulation of the Vitamin D Receptor |
Aarhus University (Faculty of Health) |
1998 |
Co-Supervisor |
|
Troels Wind |
Phage Display as a tool for elucidation of Ras biology |
Aarhus University |
1999 |
Project Supervisor |
|
Brian Stausbøl-Grøn |
solation and Characterisation of Recombinant Human Antibody Fragments From Phage Display Antibody Libraries |
Aarhus University (Faculty of Health) |
1999 |
Co-Supervisor |
|
Kristian Hobolt Jensen |
Application of phage display and understanding of the infection process |
Aarhus University |
2000 |
Project Supervisor |
|
Kim Bak Jensen |
Identification of Keratinocyte Specific Markers Using Phage Display |
Aarhus University |
2002 |
Project Supervisor |
|
Charlotte Georgi Jakobsen |
Establishment of human and murine IgE and IgG combinatorial phage libraries |
Aarhus University |
2003 |
Project Supervisor |
|
Martin Larsen |
Studies on immune presenting systems with potential of improving vaccines |
Aarhus University |
2004 |
Project Supervisor |
|
Potjamas Pansri |
Production of Antibody by phage display technology |
Suranaree University of Technology, Thailand |
2008 |
Co-Supervisor |
|
Lu Sang |
Phage antibody Technology Applied to Identify New Molecular Targets on LM-332 Positive Malignant Cells |
Aarhus University |
2008 |
Project Supervisor |
|
Louise Boisen |
Using phage display to investigate age-related changes in the proteome and their influence on angiogenesis |
Aarhus University |
2009 |
Project Supervisor |
|
Morten Dræby Sørensen |
Selection of antibodies by phage display against rare circulating cells in the peripheral bloodstream |
Aarhus Univesity |
2010 |
Supervisor |
|
Ole Aalund Mandrup |
Phage Display Libraries, Selections and Screenings for the Identification of Internalizing Antibodies and Cellular Markers |
Aarhus University |
2012 |
Supervisor |
|
Theresa Meldgaard |
Discovery of Cell Specific Biomarkers in Breast Cancer using Recombinant Antibodies |
Aarhus University |
2013 (2014 due to maternatiy leave |
Supervisor |
|
Lotte Rasmussen |
Tracing vasculogenesis in tumours – with special emphasis on characterisation and involvement of endothelial outgrowth cells |
Aarhus University |
2014 |
Co-supervisor |
|
Simon Asbjørn Larsen |
Identification and Analysis of Cell-specific Biomarkers of Breast Cancer Subpopulations by Recombinant antibody selection |
Aarhus University |
2014 |
Supervisor |
|
Jesper Just |
Exploration of the Pericyte and Oxidative Stress by Recombinant Antibody Technology |
Aarhus University |
2015 |
Supervisor |
|
Niels Anton Friis |
|
Aarhus University |
2014 |
Supervisor |
|
SimonLykkemark |
A Novel Phage Display Selection Method for Pericyte Marker Discovery |
Aarhus University |
2016 |
Supervisor |
|
Mathias Lindh Jørgensen |
Identification and Exploration of Biomarkers associated to circulating tumour cells by recombinant antibody technology |
Aarhus Universitet |
2017 |
Supervisor |
|
Emil Frank Holmquist |
Organic Reaction-Based Capture ELISA: Development of High-Throughput Screening Assays for Acetoacetate and Methylglyoxal |
Aarhus University |
2016 |
Co-supervisor |
|
Rasmus Kold-Christensen |
|
|
2019 |
Co-supervisor |
Ekspertise relateret til FN’s Verdensmål
I 2015 blev FN's medlemslande enige om 17 Verdensmål til at bekæmpe fattigdom, beskytte planeten og sikre velstand for alle. Denne persons arbejde bidrager til følgende verdensmål:
Uddannelse (Akademiske kvalifikationer)
Chemistry and Biotechnology, PhD, Aarhus University
1992 → 2 okt. 1995
Dimissionsdato: 2 okt. 1995
Chemistry and Biotechnology, MSc, Aarhus University
1 sep. 1986 → 30 jun. 1992
Dimissionsdato: 1 jun. 1992
Eksterne ansættelser
Lektor (MSK), Department of Engineering, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000, Denmark.
2010 → 2017
Lektor (MSK), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.
2003 → 2010
Senior Scientist, Aarhus Universityhospital, Denmark
2001 → 2002
Forsknings lektor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.
2000 → 2001
Forsknings Adjunkt, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.
1998 → 2000
Research Scientist, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)
1997 → 1998
Post-doctoral Fellow, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)
1995 → 1997
Emneord
- Kemi og Biovidenskab
- Biomedicin
Fingerprint
Fingerprint er automatisk genererede koncepter, som stammer fra personprofilernes indhold. Det opdateres løbende med nye registreringer.
- 1 Lignende profiler
Samarbejde i de sidste fem år
Klik på punkterne for at se detaljerne.
-
An anti vimentin antibody promotes tube formation
Jørgensen, M. L., Møller, C. K., Rasmussen, L., Boisen, L., Pedersen, H. & Kristensen, P., 15 jun. 2017, I: Scientific Reports. 7, 1, 3576.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
8 Citationer (Scopus) -
Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy
Just, J., Lykkemark, S., Nielsen, C. H., Roshenas, A. R., Drasbek, K. R., Petersen, S. V., Bek, T. & Kristensen, P., 1 aug. 2017, I: Microcirculation. 24, 6, e12365.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
3 Citationer (Scopus) -
A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections
Lykkemark, S., Mandrup, O. A., Jensen, M. B., Just, J. & Kristensen, P., 1 jun. 2017, I: Nucleic Acids Research. 45, 11, s. e107Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
4 Citationer (Scopus) -
Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.
Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T. & Kristensen, P., 1 dec. 2015, I: Free Radical Biology and Medicine. 89, s. 786-792 7 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
14 Citationer (Scopus) -
Deep mining of antibody phage-display selections using Oxford Nanopore Technologies and Dual Unique Molecular Identifiers
Mejias-Gomez, O., Braghetto, M., Sørensen, M. K. D., Madsen, A. V., Guiu, L. S., Kristensen, P., Pedersen, L. E. & Goletz, S., 25 maj 2024, I: New Biotechnology. 80, s. 56-68 13 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgang
Aktiviteter
-
Selection of peptides against human IgE-Fc using phage display
Peter Kristensen (Eksaminator)
21 jan. 2022Aktivitet: Censoraktivitet og eksaminering › Ekstern censoraktivitet
-
Discovery of single-domain antibodies against Clostridium difficile
Peter Kristensen (Eksaminator)
20 jan. 2022Aktivitet: Censoraktivitet og eksaminering › Ekstern censoraktivitet
-
Discovery of single-domain antibodies against two distinct adhesion factors of Clostridium difficile
Peter Kristensen (Eksaminator)
20 jan. 2022Aktivitet: Censoraktivitet og eksaminering › Ekstern censoraktivitet
-
Partial site-saturation and semi-rational engineering of fatty acid hydratases from Lactobacillus Acidophilus and optimization of bi-enzymatic cascade reaction system towards production of hydroxy fatty acids
Peter Kristensen (Eksaminator)
17 jan. 2022Aktivitet: Censoraktivitet og eksaminering › Ekstern censoraktivitet
-
Avidity and multivalent target engagement in antibodies
Peter Kristensen (Eksaminator)
17 jan. 2022Aktivitet: Censoraktivitet og eksaminering › Ekstern censoraktivitet
Presse/medier
-
Se video: Her er, hvad du skal vide om coronavirussen
31/01/2020
1 element af Mediedækning
Presse/medie
-
-
Innovativt dansk forsøg kan bane vejen for bedre slange-modgift
20/06/2022 → 23/06/2022
3 elementer af Mediedækning
Presse/medie
-
Virus viser vej til modgift mod slangebid
12/08/2020 → 17/08/2020
10 elementer af Mediedækning
Presse/medie
-
Nordjysk virus-forsker: Derfor skal du ikke være nervøs for corona
27/02/2020
1 element af Mediedækning
Presse/medie