Abstract
Diabetes mellitus is associated with an increased risk of fracture with and current fracture predictors underestimate fracture risk in both type 1 and type 2 diabetes. Thus, further understanding of the underlying causes of diabetic bone disease may lead to better fracture predictors and preventive measures in patients with diabetes.
This PhD thesis reports the results of two systematic reviews and a meta-analysis, a state-of-the-art intervention study, a clinical cross-sectional study and a registry-based study all examining the relationship between diabetes, glucose, and bone.
Patients with type 2 diabetes had lower bone turnover markers compared to patients with type 1 diabetes and bone mineral density and tissue stiffness were increased in patients with type 2 diabetes. The bone turnover markers were inversely associated with blood glucose in patients with diabetes and both an oral glucose tolerance test and an intravenous test decreased bone resorption markers in healthy men. In the registry based study; fracture risk in patients with type 2 diabetes were associated with low LDL-cholesterol levels.
In patients with diabetes, bone turnover and bone strength are associated with clinically relevant measures such as cholesterols and fluctuate on the basis of blood glucose level alterations.
This PhD thesis reports the results of two systematic reviews and a meta-analysis, a state-of-the-art intervention study, a clinical cross-sectional study and a registry-based study all examining the relationship between diabetes, glucose, and bone.
Patients with type 2 diabetes had lower bone turnover markers compared to patients with type 1 diabetes and bone mineral density and tissue stiffness were increased in patients with type 2 diabetes. The bone turnover markers were inversely associated with blood glucose in patients with diabetes and both an oral glucose tolerance test and an intravenous test decreased bone resorption markers in healthy men. In the registry based study; fracture risk in patients with type 2 diabetes were associated with low LDL-cholesterol levels.
In patients with diabetes, bone turnover and bone strength are associated with clinically relevant measures such as cholesterols and fluctuate on the basis of blood glucose level alterations.
| Bidragets oversatte titel | Undersøgelser af diabetisk knoglesygdom: Literatur, register og kliniske studier |
|---|---|
| Originalsprog | Engelsk |
| Udgiver | |
| ISBN'er, elektronisk | 978-87-7112-340-1 |
| DOI | |
| Status | Udgivet - 2015 |
Bibliografisk note
Peter Vestergaard, HovedvejlederSøren Gregersen, Bivejleder
Bente Lomholt Langdahl, Bivejleder
Ellen-Margrethe Hauge, Bivejleder