TY - JOUR
T1 - Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity
AU - Wang, Yongming
AU - Zou, Lai-quan
AU - Xie, Wen-lan
AU - Yang, Zhuo-ya
AU - Zhu, Xiong-zhao
AU - Cheung, Eric F. C.
AU - Sørensen, Thomas Alrik
AU - Møller, Arne
AU - Chan, Raymond C.K.
PY - 2018/6/30
Y1 - 2018/6/30
N2 - Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.
AB - Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.
KW - Schizo-obsessive comorbidity
KW - Schizophrenia, obsessive-compulsive disorder
KW - Grey matter volume
KW - Cortical thickness
U2 - 10.1016/j.pscychresns.2018.03.009
DO - 10.1016/j.pscychresns.2018.03.009
M3 - Journal article
SN - 0925-4927
VL - 276
SP - 65
EP - 72
JO - Psychiatry Research: Neuroimaging
JF - Psychiatry Research: Neuroimaging
ER -