TY - JOUR
T1 - Atrial Fibrillation and Cognitive Function
T2 - JACC Review Topic of the Week
AU - Diener, Hans Christoph
AU - Hart, Robert G.
AU - Koudstaal, Peter J.
AU - Lane, Deirdre A.
AU - Lip, Gregory Y.H.
PY - 2019/2
Y1 - 2019/2
N2 - Numerous vascular risk factors and vascular diseases contribute to cognitive impairment and dementia. Many studies and registries show an association of atrial fibrillation (AF) with cognitive impairment, cognitive decline, and dementia. This is true for vascular dementia and Alzheimer's disease. The assumed multifactorial mechanisms include ischemic stroke, both apparent and silent, cerebral microinfarcts, cerebral hemorrhage, and reduced cerebral blood flow. A number of retrospective observational and prospective studies support that anticoagulation in patients with AF may reduce the risk of cognitive decline and dementia. This holds for both vitamin K antagonists (e.g., warfarin) and direct oral anticoagulants. However, it still remains unproven if anticoagulation reduces cognitive decline and dementia in AF patients based on randomized trials.
AB - Numerous vascular risk factors and vascular diseases contribute to cognitive impairment and dementia. Many studies and registries show an association of atrial fibrillation (AF) with cognitive impairment, cognitive decline, and dementia. This is true for vascular dementia and Alzheimer's disease. The assumed multifactorial mechanisms include ischemic stroke, both apparent and silent, cerebral microinfarcts, cerebral hemorrhage, and reduced cerebral blood flow. A number of retrospective observational and prospective studies support that anticoagulation in patients with AF may reduce the risk of cognitive decline and dementia. This holds for both vitamin K antagonists (e.g., warfarin) and direct oral anticoagulants. However, it still remains unproven if anticoagulation reduces cognitive decline and dementia in AF patients based on randomized trials.
KW - anticoagulation
KW - atrial fibrillation
KW - cognitive impairment
KW - dementia
UR - http://www.scopus.com/inward/record.url?scp=85060539844&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2018.10.077
DO - 10.1016/j.jacc.2018.10.077
M3 - Review article
AN - SCOPUS:85060539844
SN - 0735-1097
VL - 73
SP - 612
EP - 619
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 5
ER -