Broadband diffuse optical characterization of elastin for biomedical applications

Sanathana Konugolu Venkata Sekar; Joo Sin Beh; Andrea Farina; Alberto Dalla Mora; Antonio Pifferi; Paola Taroni

doi:10.1016/j.bpc.2017.07.004

Broadband diffuse optical characterization of elastin for biomedical applications

Sanathana Konugolu Venkata Sekar, Joo Sin Beh, Andrea Farina, Alberto Dalla Mora, Antonio Pifferi, Paola Taroni

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

12 Citationer (Scopus)

Abstract

Elastin is a key structural protein of dynamic connective tissues widely found in the extracellular matrix of skin, arteries, lungs and ligaments. It is responsible for a range of diseases related to aging of biological tissues. The optical characterization of elastin can open new opportunities for its investigation in biomedical studies. In this work, we present the absorption spectra of elastin using a broadband (550-1350nm) diffuse optical spectrometer. Distortions caused by fluorescence and finite bandwidth of the laser source on estimated absorption were effectively accounted for in measurements and data analysis and compensated. A comprehensive summary and comparison between collagen and elastin is presented, highlighting distinct features for its accurate quantification in biological applications.

Originalsprog	Engelsk
Tidsskrift	Biophysical Chemistry
Vol/bind	229
Sider (fra-til)	130-134
ISSN	0301-4622
DOI	https://doi.org/10.1016/j.bpc.2017.07.004
Status	Udgivet - okt. 2017

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10.1016/j.bpc.2017.07.004

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title = "Broadband diffuse optical characterization of elastin for biomedical applications",

abstract = "Elastin is a key structural protein of dynamic connective tissues widely found in the extracellular matrix of skin, arteries, lungs and ligaments. It is responsible for a range of diseases related to aging of biological tissues. The optical characterization of elastin can open new opportunities for its investigation in biomedical studies. In this work, we present the absorption spectra of elastin using a broadband (550-1350nm) diffuse optical spectrometer. Distortions caused by fluorescence and finite bandwidth of the laser source on estimated absorption were effectively accounted for in measurements and data analysis and compensated. A comprehensive summary and comparison between collagen and elastin is presented, highlighting distinct features for its accurate quantification in biological applications.",

keywords = "Animals, Cattle, Elastin, Extracellular Matrix, Spectrophotometry, Infrared, Journal Article",

author = "{Konugolu Venkata Sekar}, Sanathana and Beh, {Joo Sin} and Andrea Farina and {Dalla Mora}, Alberto and Antonio Pifferi and Paola Taroni",

year = "2017",

month = oct,

doi = "10.1016/j.bpc.2017.07.004",

language = "English",

volume = "229",

pages = "130--134",

journal = "Biophysical Chemistry",

issn = "0301-4622",

publisher = "Elsevier",

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TY - JOUR

T1 - Broadband diffuse optical characterization of elastin for biomedical applications

AU - Konugolu Venkata Sekar, Sanathana

AU - Beh, Joo Sin

AU - Farina, Andrea

AU - Dalla Mora, Alberto

AU - Pifferi, Antonio

AU - Taroni, Paola

PY - 2017/10

Y1 - 2017/10

N2 - Elastin is a key structural protein of dynamic connective tissues widely found in the extracellular matrix of skin, arteries, lungs and ligaments. It is responsible for a range of diseases related to aging of biological tissues. The optical characterization of elastin can open new opportunities for its investigation in biomedical studies. In this work, we present the absorption spectra of elastin using a broadband (550-1350nm) diffuse optical spectrometer. Distortions caused by fluorescence and finite bandwidth of the laser source on estimated absorption were effectively accounted for in measurements and data analysis and compensated. A comprehensive summary and comparison between collagen and elastin is presented, highlighting distinct features for its accurate quantification in biological applications.

AB - Elastin is a key structural protein of dynamic connective tissues widely found in the extracellular matrix of skin, arteries, lungs and ligaments. It is responsible for a range of diseases related to aging of biological tissues. The optical characterization of elastin can open new opportunities for its investigation in biomedical studies. In this work, we present the absorption spectra of elastin using a broadband (550-1350nm) diffuse optical spectrometer. Distortions caused by fluorescence and finite bandwidth of the laser source on estimated absorption were effectively accounted for in measurements and data analysis and compensated. A comprehensive summary and comparison between collagen and elastin is presented, highlighting distinct features for its accurate quantification in biological applications.

KW - Animals

KW - Cattle

KW - Elastin

KW - Extracellular Matrix

KW - Spectrophotometry, Infrared

KW - Journal Article

U2 - 10.1016/j.bpc.2017.07.004

DO - 10.1016/j.bpc.2017.07.004

M3 - Journal article

C2 - 28733103

SN - 0301-4622

VL - 229

SP - 130

EP - 134

JO - Biophysical Chemistry

JF - Biophysical Chemistry

ER -

Broadband diffuse optical characterization of elastin for biomedical applications

Abstract

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