Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis

Angel Cheung; Mengqi Gong; Roberto Bellanti; Sadeq Ali-Hasan-Al-Saegh; Guangping Li; Eulàlia Roig; Julio Núñez; Thomas D Stamos; Mehmet Birhan Yilmaz; Kaya Hakki; William K K Wu; Sunny Hei Wong; Wing Tak Wong; George Bazoukis; Konstantinos Lampropoulos; Lah Ah Tse; Jichao Zhao; Gregory Y H Lip; Adrian Baranchuk; Martin C S Wong; Tong Liu; Gary Tse

doi:10.1136/heartasia-2017-010970

Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis

Angel Cheung, Mengqi Gong, Roberto Bellanti, Sadeq Ali-Hasan-Al-Saegh, Guangping Li, Eulàlia Roig, Julio Núñez, Thomas D Stamos, Mehmet Birhan Yilmaz, Kaya Hakki, William K K Wu, Sunny Hei Wong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Lah Ah Tse, Jichao Zhao, Gregory Y H Lip, Adrian Baranchuk, Martin C S WongTong Liu, Gary Tse

Publikation: Bidrag til tidsskrift › Review (oversigtsartikel) › peer review

18 Citationer (Scopus)

Abstract

Background: Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.

Methods: PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.

Results: A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%).

Conclusion: Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.

Originalsprog	Engelsk
Artikelnummer	010970
Tidsskrift	Heart Asia
Vol/bind	10
Udgave nummer	1
Sider (fra-til)	e010970
Antal sider	6
ISSN	1759-1104
DOI	https://doi.org/10.1136/heartasia-2017-010970
Status	Udgivet - 1 jan. 2018

Adgang til dokumentet

10.1136/heartasia-2017-010970

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771018

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Andre filer og links

http://www.scopus.com/inward/record.url?scp=85041553016&partnerID=8YFLogxK

Citationsformater

Cheung, A., Gong, M., Bellanti, R., Ali-Hasan-Al-Saegh, S., Li, G., Roig, E., Núñez, J., Stamos, T. D., Yilmaz, M. B., Hakki, K., Wu, W. K. K., Wong, S. H., Wong, W. T., Bazoukis, G., Lampropoulos, K., Tse, L. A., Zhao, J., Lip, G. Y. H., Baranchuk, A., ... Tse, G. (2018). Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis. Heart Asia, 10(1), e010970. Artikel 010970. https://doi.org/10.1136/heartasia-2017-010970

@article{76b1e8e4d3014f0faeee6d4388e61caf,

title = "Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis",

abstract = "Background: Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.Methods: PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.Results: A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%).Conclusion: Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.",

keywords = "Journal Article",

author = "Angel Cheung and Mengqi Gong and Roberto Bellanti and Sadeq Ali-Hasan-Al-Saegh and Guangping Li and Eul{\`a}lia Roig and Julio N{\'u}{\~n}ez and Stamos, {Thomas D} and Yilmaz, {Mehmet Birhan} and Kaya Hakki and Wu, {William K K} and Wong, {Sunny Hei} and Wong, {Wing Tak} and George Bazoukis and Konstantinos Lampropoulos and Tse, {Lah Ah} and Jichao Zhao and Lip, {Gregory Y H} and Adrian Baranchuk and Wong, {Martin C S} and Tong Liu and Gary Tse",

year = "2018",

month = jan,

day = "1",

doi = "10.1136/heartasia-2017-010970",

language = "English",

volume = "10",

pages = "e010970",

journal = "Heart Asia",

issn = "1759-1104",

publisher = "B M J Group",

number = "1",

}

Cheung, A, Gong, M, Bellanti, R, Ali-Hasan-Al-Saegh, S, Li, G, Roig, E, Núñez, J, Stamos, TD, Yilmaz, MB, Hakki, K, Wu, WKK, Wong, SH, Wong, WT, Bazoukis, G, Lampropoulos, K, Tse, LA, Zhao, J, Lip, GYH, Baranchuk, A, Wong, MCS, Liu, T & Tse, G 2018, 'Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis', Heart Asia, bind 10, nr. 1, 010970, s. e010970. https://doi.org/10.1136/heartasia-2017-010970

TY - JOUR

T1 - Cancer antigen-125 and risk of atrial fibrillation

T2 - a systematic review and meta-analysis

AU - Cheung, Angel

AU - Gong, Mengqi

AU - Bellanti, Roberto

AU - Ali-Hasan-Al-Saegh, Sadeq

AU - Li, Guangping

AU - Roig, Eulàlia

AU - Núñez, Julio

AU - Stamos, Thomas D

AU - Yilmaz, Mehmet Birhan

AU - Hakki, Kaya

AU - Wu, William K K

AU - Wong, Sunny Hei

AU - Wong, Wing Tak

AU - Bazoukis, George

AU - Lampropoulos, Konstantinos

AU - Tse, Lah Ah

AU - Zhao, Jichao

AU - Lip, Gregory Y H

AU - Baranchuk, Adrian

AU - Wong, Martin C S

AU - Liu, Tong

AU - Tse, Gary

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.Methods: PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.Results: A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%).Conclusion: Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.

AB - Background: Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.Methods: PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.Results: A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%).Conclusion: Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85041553016&partnerID=8YFLogxK

U2 - 10.1136/heartasia-2017-010970

DO - 10.1136/heartasia-2017-010970

M3 - Review article

C2 - 29387174

SN - 1759-1104

VL - 10

SP - e010970

JO - Heart Asia

JF - Heart Asia

IS - 1

M1 - 010970

ER -

Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis

Abstract

Adgang til dokumentet

AUB Link

Andre filer og links

Fingeraftryk

Citationsformater