TY - JOUR
T1 - Chocolate intake and risk of clinically apparent atrial fibrillation
T2 - the Danish Diet, Cancer, and Health Study
AU - Mostofsky, Elizabeth
AU - Berg Johansen, Martin
AU - Tjønneland, Anne
AU - Chahal, Harpreet S
AU - Mittleman, Murray A
AU - Overvad, Kim
N1 - This article has been found as a 'Free Version' from the Publisher on July 26th 2018. When the access to the article closes, please notify vbn@aub.aau.dk
PY - 2017
Y1 - 2017
N2 - OBJECTIVE: To evaluate the association between chocolate intake and incident clinically apparent atrial fibrillation or flutter (AF).METHODS: The Danish Diet, Cancer, and Health Study is a large population-based prospective cohort study. The present study is based on 55 502 participants (26 400 men and 29 102 women) aged 50-64 years who had provided information on chocolate intake at baseline. Incident cases of AF were ascertained by linkage with nationwide registries.RESULTS: During a median of 13.5 years there were 3346 cases of AF. Compared with chocolate intake less than once per month, the rate of AF was lower for people consuming 1-3 servings/month (hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.82 to 0.98), 1 serving/week (HR 0.83, 95% CI 0.74 to 0.92), 2-6 servings/week (HR 0.80, 95% CI 0.71 to 0.91) and ≥1 servings/day (HR 0.84, 95% CI 0.65 to 1.09; p-linear trend <0.0001), with similar results for men and women.CONCLUSIONS: Accumulating evidence indicates that moderate chocolate intake may be inversely associated with AF risk, although residual confounding cannot be ruled out.
AB - OBJECTIVE: To evaluate the association between chocolate intake and incident clinically apparent atrial fibrillation or flutter (AF).METHODS: The Danish Diet, Cancer, and Health Study is a large population-based prospective cohort study. The present study is based on 55 502 participants (26 400 men and 29 102 women) aged 50-64 years who had provided information on chocolate intake at baseline. Incident cases of AF were ascertained by linkage with nationwide registries.RESULTS: During a median of 13.5 years there were 3346 cases of AF. Compared with chocolate intake less than once per month, the rate of AF was lower for people consuming 1-3 servings/month (hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.82 to 0.98), 1 serving/week (HR 0.83, 95% CI 0.74 to 0.92), 2-6 servings/week (HR 0.80, 95% CI 0.71 to 0.91) and ≥1 servings/day (HR 0.84, 95% CI 0.65 to 1.09; p-linear trend <0.0001), with similar results for men and women.CONCLUSIONS: Accumulating evidence indicates that moderate chocolate intake may be inversely associated with AF risk, although residual confounding cannot be ruled out.
KW - Journal Article
UR - https://heart.bmj.com/content/heartjnl/103/15/1163.full.pdf
U2 - 10.1136/heartjnl-2016-310357
DO - 10.1136/heartjnl-2016-310357
M3 - Journal article
C2 - 28536115
SN - 1355-6037
VL - 103
SP - 1163
EP - 1167
JO - Heart
JF - Heart
IS - 5
ER -