Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation: The Chinese Atrial Fibrillation Registry Study

San-Shuai Chang; Jian-Zeng Dong; Chang-Sheng Ma; Xin Du; Jia-Hui Wu; Ri-Bo Tang; Shi-Jun Xia; Xue-Yuan Guo; Rong-Hui Yu; De-Yong Long; Rong Bai; Nian Liu; Cai-Hua Sang; Chen-Xi Jiang; Xiao-Hui Liu; Jian-Hong Pan; Gregory Y H Lip

doi:10.1161/STROKEAHA.116.012988

Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation: The Chinese Atrial Fibrillation Registry Study

San-Shuai Chang, Jian-Zeng Dong, Chang-Sheng Ma, Xin Du, Jia-Hui Wu, Ri-Bo Tang, Shi-Jun Xia, Xue-Yuan Guo, Rong-Hui Yu, De-Yong Long, Rong Bai, Nian Liu, Cai-Hua Sang, Chen-Xi Jiang, Xiao-Hui Liu, Jian-Hong Pan, Gregory Y H Lip

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

93 Citationer (Scopus)

Abstract

BACKGROUND AND PURPOSE: Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be changing over time. We aimed to explore the current status and time trends of OAC use in Beijing.

METHODS: We used the data set from the Chinese Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospital-based registry study involving 20 tertiary and 12 nontertiary hospitals in Beijing. A total of 11 496 patients with AF were enrolled from 2011 to 2014.

RESULTS: Seven thousand nine hundred seventy-seven eligible patients were included in this ancillary study. The proportions of OAC use were 36.5% (2268/6210), 28.5% (333/1168), and 21.4% (128/599) for patients with CHA2DS2-VASc scores ≥2, 1, and 0, respectively. Persistent AF, history of stroke/transient ischemic attack/peripheral embolism, diabetes mellitus, higher body mass index, and tertiary hospital management were factors positively associated with OAC use, whereas older age, previous bleeding, hypercholesterolemia, and established coronary artery disease were factors negatively associated with OAC use. Among patients with CHADS2 scores ≥2 and CHA2DS2-VASc scores ≥2, the proportion of OAC use increased from 31.3% to 64.5% and 30.2% to 57.7%, respectively, from 2011 to 2014. Variation in OAC use was substantial among different hospitals.

CONCLUSIONS: An improvement of OAC use among Chinese patients with AF in Beijing is observed in recent years although only 36.5% of patients with CHA2DS2-VASc score ≥2 received OAC. However, variations between different hospitals were large, suggesting that better education and awareness are needed to improve efforts for stroke prevention among AF patients.

CLINICAL TRIAL REGISTRATION: URL: http://www.chictr.org.cn/showproj.aspx?proj=5831. Unique identifier: ChiCTR-OCH-13003729.

Originalsprog	Engelsk
Tidsskrift	Stroke
Vol/bind	47
Udgave nummer	7
Sider (fra-til)	1803-1810
Antal sider	8
ISSN	0039-2499
DOI	https://doi.org/10.1161/STROKEAHA.116.012988
Status	Udgivet - 2016
Udgivet eksternt	Ja

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10.1161/STROKEAHA.116.012988

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Chang, S-S., Dong, J-Z., Ma, C-S., Du, X., Wu, J-H., Tang, R-B., Xia, S-J., Guo, X-Y., Yu, R-H., Long, D-Y., Bai, R., Liu, N., Sang, C-H., Jiang, C-X., Liu, X-H., Pan, J-H., & Lip, G. Y. H. (2016). Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation: The Chinese Atrial Fibrillation Registry Study. Stroke, 47(7), 1803-1810. https://doi.org/10.1161/STROKEAHA.116.012988

@article{c9718660ab0e497687180f5a61ba1bd9,

title = "Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation: The Chinese Atrial Fibrillation Registry Study",

abstract = "BACKGROUND AND PURPOSE: Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be changing over time. We aimed to explore the current status and time trends of OAC use in Beijing.METHODS: We used the data set from the Chinese Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospital-based registry study involving 20 tertiary and 12 nontertiary hospitals in Beijing. A total of 11 496 patients with AF were enrolled from 2011 to 2014.RESULTS: Seven thousand nine hundred seventy-seven eligible patients were included in this ancillary study. The proportions of OAC use were 36.5% (2268/6210), 28.5% (333/1168), and 21.4% (128/599) for patients with CHA2DS2-VASc scores ≥2, 1, and 0, respectively. Persistent AF, history of stroke/transient ischemic attack/peripheral embolism, diabetes mellitus, higher body mass index, and tertiary hospital management were factors positively associated with OAC use, whereas older age, previous bleeding, hypercholesterolemia, and established coronary artery disease were factors negatively associated with OAC use. Among patients with CHADS2 scores ≥2 and CHA2DS2-VASc scores ≥2, the proportion of OAC use increased from 31.3% to 64.5% and 30.2% to 57.7%, respectively, from 2011 to 2014. Variation in OAC use was substantial among different hospitals.CONCLUSIONS: An improvement of OAC use among Chinese patients with AF in Beijing is observed in recent years although only 36.5% of patients with CHA2DS2-VASc score ≥2 received OAC. However, variations between different hospitals were large, suggesting that better education and awareness are needed to improve efforts for stroke prevention among AF patients.CLINICAL TRIAL REGISTRATION: URL: http://www.chictr.org.cn/showproj.aspx?proj=5831. Unique identifier: ChiCTR-OCH-13003729.",

author = "San-Shuai Chang and Jian-Zeng Dong and Chang-Sheng Ma and Xin Du and Jia-Hui Wu and Ri-Bo Tang and Shi-Jun Xia and Xue-Yuan Guo and Rong-Hui Yu and De-Yong Long and Rong Bai and Nian Liu and Cai-Hua Sang and Chen-Xi Jiang and Xiao-Hui Liu and Jian-Hong Pan and Lip, {Gregory Y H}",

note = "{\textcopyright} 2016 American Heart Association, Inc.",

year = "2016",

doi = "10.1161/STROKEAHA.116.012988",

language = "English",

volume = "47",

pages = "1803--1810",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams & Wilkins",

number = "7",

}

Chang, S-S, Dong, J-Z, Ma, C-S, Du, X, Wu, J-H, Tang, R-B, Xia, S-J, Guo, X-Y, Yu, R-H, Long, D-Y, Bai, R, Liu, N, Sang, C-H, Jiang, C-X, Liu, X-H, Pan, J-H & Lip, GYH 2016, 'Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation: The Chinese Atrial Fibrillation Registry Study', Stroke, bind 47, nr. 7, s. 1803-1810. https://doi.org/10.1161/STROKEAHA.116.012988

TY - JOUR

T1 - Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation

T2 - The Chinese Atrial Fibrillation Registry Study

AU - Chang, San-Shuai

AU - Dong, Jian-Zeng

AU - Ma, Chang-Sheng

AU - Du, Xin

AU - Wu, Jia-Hui

AU - Tang, Ri-Bo

AU - Xia, Shi-Jun

AU - Guo, Xue-Yuan

AU - Yu, Rong-Hui

AU - Long, De-Yong

AU - Bai, Rong

AU - Liu, Nian

AU - Sang, Cai-Hua

AU - Jiang, Chen-Xi

AU - Liu, Xiao-Hui

AU - Pan, Jian-Hong

AU - Lip, Gregory Y H

PY - 2016

Y1 - 2016

N2 - BACKGROUND AND PURPOSE: Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be changing over time. We aimed to explore the current status and time trends of OAC use in Beijing.METHODS: We used the data set from the Chinese Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospital-based registry study involving 20 tertiary and 12 nontertiary hospitals in Beijing. A total of 11 496 patients with AF were enrolled from 2011 to 2014.RESULTS: Seven thousand nine hundred seventy-seven eligible patients were included in this ancillary study. The proportions of OAC use were 36.5% (2268/6210), 28.5% (333/1168), and 21.4% (128/599) for patients with CHA2DS2-VASc scores ≥2, 1, and 0, respectively. Persistent AF, history of stroke/transient ischemic attack/peripheral embolism, diabetes mellitus, higher body mass index, and tertiary hospital management were factors positively associated with OAC use, whereas older age, previous bleeding, hypercholesterolemia, and established coronary artery disease were factors negatively associated with OAC use. Among patients with CHADS2 scores ≥2 and CHA2DS2-VASc scores ≥2, the proportion of OAC use increased from 31.3% to 64.5% and 30.2% to 57.7%, respectively, from 2011 to 2014. Variation in OAC use was substantial among different hospitals.CONCLUSIONS: An improvement of OAC use among Chinese patients with AF in Beijing is observed in recent years although only 36.5% of patients with CHA2DS2-VASc score ≥2 received OAC. However, variations between different hospitals were large, suggesting that better education and awareness are needed to improve efforts for stroke prevention among AF patients.CLINICAL TRIAL REGISTRATION: URL: http://www.chictr.org.cn/showproj.aspx?proj=5831. Unique identifier: ChiCTR-OCH-13003729.

AB - BACKGROUND AND PURPOSE: Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be changing over time. We aimed to explore the current status and time trends of OAC use in Beijing.METHODS: We used the data set from the Chinese Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospital-based registry study involving 20 tertiary and 12 nontertiary hospitals in Beijing. A total of 11 496 patients with AF were enrolled from 2011 to 2014.RESULTS: Seven thousand nine hundred seventy-seven eligible patients were included in this ancillary study. The proportions of OAC use were 36.5% (2268/6210), 28.5% (333/1168), and 21.4% (128/599) for patients with CHA2DS2-VASc scores ≥2, 1, and 0, respectively. Persistent AF, history of stroke/transient ischemic attack/peripheral embolism, diabetes mellitus, higher body mass index, and tertiary hospital management were factors positively associated with OAC use, whereas older age, previous bleeding, hypercholesterolemia, and established coronary artery disease were factors negatively associated with OAC use. Among patients with CHADS2 scores ≥2 and CHA2DS2-VASc scores ≥2, the proportion of OAC use increased from 31.3% to 64.5% and 30.2% to 57.7%, respectively, from 2011 to 2014. Variation in OAC use was substantial among different hospitals.CONCLUSIONS: An improvement of OAC use among Chinese patients with AF in Beijing is observed in recent years although only 36.5% of patients with CHA2DS2-VASc score ≥2 received OAC. However, variations between different hospitals were large, suggesting that better education and awareness are needed to improve efforts for stroke prevention among AF patients.CLINICAL TRIAL REGISTRATION: URL: http://www.chictr.org.cn/showproj.aspx?proj=5831. Unique identifier: ChiCTR-OCH-13003729.

U2 - 10.1161/STROKEAHA.116.012988

DO - 10.1161/STROKEAHA.116.012988

M3 - Journal article

C2 - 27283198

SN - 0039-2499

VL - 47

SP - 1803

EP - 1810

JO - Stroke

JF - Stroke

IS - 7

ER -

Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation: The Chinese Atrial Fibrillation Registry Study

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