TY - JOUR
T1 - Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
AU - Tsilidis, Konstantinos K
AU - Allen, Naomi E
AU - Appleby, Paul N
AU - Rohrmann, Sabine
AU - Nöthlings, Ute
AU - Arriola, Larraitz
AU - Gunter, Marc J
AU - Chajes, Veronique
AU - Rinaldi, Sabina
AU - Romieu, Isabelle
AU - Murphy, Neil
AU - Riboli, Elio
AU - Tzoulaki, Ioanna
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Pischon, Tobias
AU - Dahm, Christina C
AU - Overvad, Kim
AU - Quirós, J Ramón
AU - Fonseca-Nunes, Ana
AU - Molina-Montes, Esther
AU - Gavrila Chervase, Diana
AU - Ardanaz, Eva
AU - Khaw, Kay T
AU - Wareham, Nick J
AU - Roswall, Nina
AU - Tjønneland, Anne
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Trichopoulou, Antonia
AU - Palli, Domenico
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Bueno-de-Mesquita, H Bas
AU - Malm, Johan
AU - Orho-Melander, Marju
AU - Johansson, Mattias
AU - Stattin, Pär
AU - Travis, Ruth C
AU - Key, Timothy J
N1 - Copyright © 2014 UICC.
PY - 2015
Y1 - 2015
N2 - The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC). Among 139,131 eligible men, 4,531 were diagnosed with prostate cancer over an average follow-up of 12 years. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by EPIC-participating center and age at recruitment, and adjusted for education, smoking status, body mass index, waist circumference, and physical activity. In a subset of men without prostate cancer, the cross-sectional association between circulating concentrations of androgens and insulin-like growth factor proteins with diabetes status was also investigated using linear regression models. Compared to men with no diabetes, men with diabetes had a 26% lower risk of prostate cancer (HR, 0.74; 95% CI, 0.63 - 0.86). There was no evidence that the association differed by stage (P-heterogeneity, 0.19) or grade (P-heterogeneity, 0.48) of the disease, although the numbers were small in some disease subgroups. In a subset of 626 men with hormone measurements, circulating concentrations of androstenedione, total testosterone and insulin-like growth factor binding protein-three were lower in men with diabetes compared to men without diabetes. This large European study has confirmed an inverse association between self-reported diabetes mellitus and subsequent risk of prostate cancer. © 2014 Wiley Periodicals, Inc.
AB - The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC). Among 139,131 eligible men, 4,531 were diagnosed with prostate cancer over an average follow-up of 12 years. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by EPIC-participating center and age at recruitment, and adjusted for education, smoking status, body mass index, waist circumference, and physical activity. In a subset of men without prostate cancer, the cross-sectional association between circulating concentrations of androgens and insulin-like growth factor proteins with diabetes status was also investigated using linear regression models. Compared to men with no diabetes, men with diabetes had a 26% lower risk of prostate cancer (HR, 0.74; 95% CI, 0.63 - 0.86). There was no evidence that the association differed by stage (P-heterogeneity, 0.19) or grade (P-heterogeneity, 0.48) of the disease, although the numbers were small in some disease subgroups. In a subset of 626 men with hormone measurements, circulating concentrations of androstenedione, total testosterone and insulin-like growth factor binding protein-three were lower in men with diabetes compared to men without diabetes. This large European study has confirmed an inverse association between self-reported diabetes mellitus and subsequent risk of prostate cancer. © 2014 Wiley Periodicals, Inc.
U2 - 10.1002/ijc.28989
DO - 10.1002/ijc.28989
M3 - Journal article
C2 - 24862312
SN - 0020-7136
VL - 136
SP - 372
EP - 381
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 2
ER -