Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

Nanna Aue Sobol; Kristine Hoffmann; Kristian Steen Frederiksen; Asmus Vogel; Karsten Vestergaard; Hans Brændgaard; Hanne Gottrup; Annette Lolk; Lene Wermuth; Søren Jakobsen; Lars Laugesen; Robert Gergelyffy; Peter Høgh; Eva Bjerregaard; Volkert Siersma; Birgitte Bo Andersen; Peter Johannsen; Gunhild Waldemar; Steen Gregers Hasselbalch; Nina Beyer

doi:10.1016/j.jalz.2016.05.004

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

Nanna Aue Sobol, Kristine Hoffmann, Kristian Steen Frederiksen, Asmus Vogel, Karsten Vestergaard, Hans Brændgaard, Hanne Gottrup, Annette Lolk, Lene Wermuth, Søren Jakobsen, Lars Laugesen, Robert Gergelyffy, Peter Høgh, Eva Bjerregaard, Volkert Siersma, Birgitte Bo Andersen, Peter Johannsen, Gunhild Waldemar, Steen Gregers Hasselbalch, Nina Beyer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

76 Citationer (Scopus)

Abstract

Introduction
Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.

Methods
The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.

Results
Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.

Discussion
Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.

Originalsprog	Engelsk
Tidsskrift	Alzheimer's & Dementia
Vol/bind	12
Udgave nummer	12
Sider (fra-til)	1207-1215
Antal sider	9
ISSN	1552-5260
DOI	https://doi.org/10.1016/j.jalz.2016.05.004
Status	Udgivet - 2016

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10.1016/j.jalz.2016.05.004

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Citationsformater

Sobol, N. A., Hoffmann, K., Frederiksen, K. S., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jakobsen, S., Laugesen, L., Gergelyffy, R., Høgh, P., Bjerregaard, E., Siersma, V., Andersen, B. B., Johannsen, P., Waldemar, G., Hasselbalch, S. G., & Beyer, N. (2016). Effect of aerobic exercise on physical performance in patients with Alzheimer's disease. Alzheimer's & Dementia, 12(12), 1207-1215. Advance online publication. https://doi.org/10.1016/j.jalz.2016.05.004

@article{c6c3a7f30e70410abf99431fa5cbcc1d,

title = "Effect of aerobic exercise on physical performance in patients with Alzheimer's disease",

abstract = "IntroductionKnowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.MethodsThe single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.ResultsSignificant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.DiscussionAerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.",

author = "Sobol, {Nanna Aue} and Kristine Hoffmann and Frederiksen, {Kristian Steen} and Asmus Vogel and Karsten Vestergaard and Hans Br{\ae}ndgaard and Hanne Gottrup and Annette Lolk and Lene Wermuth and S{\o}ren Jakobsen and Lars Laugesen and Robert Gergelyffy and Peter H{\o}gh and Eva Bjerregaard and Volkert Siersma and Andersen, {Birgitte Bo} and Peter Johannsen and Gunhild Waldemar and Hasselbalch, {Steen Gregers} and Nina Beyer",

year = "2016",

doi = "10.1016/j.jalz.2016.05.004",

language = "English",

volume = "12",

pages = "1207--1215",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "12",

}

Sobol, NA, Hoffmann, K, Frederiksen, KS, Vogel, A, Vestergaard, K, Brændgaard, H, Gottrup, H, Lolk, A, Wermuth, L, Jakobsen, S, Laugesen, L, Gergelyffy, R, Høgh, P, Bjerregaard, E, Siersma, V, Andersen, BB, Johannsen, P, Waldemar, G, Hasselbalch, SG & Beyer, N 2016, 'Effect of aerobic exercise on physical performance in patients with Alzheimer's disease', Alzheimer's & Dementia, bind 12, nr. 12, s. 1207-1215. https://doi.org/10.1016/j.jalz.2016.05.004

TY - JOUR

T1 - Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

AU - Sobol, Nanna Aue

AU - Hoffmann, Kristine

AU - Frederiksen, Kristian Steen

AU - Vogel, Asmus

AU - Vestergaard, Karsten

AU - Brændgaard, Hans

AU - Gottrup, Hanne

AU - Lolk, Annette

AU - Wermuth, Lene

AU - Jakobsen, Søren

AU - Laugesen, Lars

AU - Gergelyffy, Robert

AU - Høgh, Peter

AU - Bjerregaard, Eva

AU - Siersma, Volkert

AU - Andersen, Birgitte Bo

AU - Johannsen, Peter

AU - Waldemar, Gunhild

AU - Hasselbalch, Steen Gregers

AU - Beyer, Nina

PY - 2016

Y1 - 2016

N2 - IntroductionKnowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.MethodsThe single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.ResultsSignificant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.DiscussionAerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.

AB - IntroductionKnowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.MethodsThe single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.ResultsSignificant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.DiscussionAerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.

U2 - 10.1016/j.jalz.2016.05.004

DO - 10.1016/j.jalz.2016.05.004

M3 - Journal article

C2 - 27344641

SN - 1552-5260

VL - 12

SP - 1207

EP - 1215

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 12

ER -

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

Abstract

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