TY - JOUR
T1 - Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality
T2 - results from the Copenhagen ECG study
AU - Bachmann, Troels N.
AU - Skov, Morten W.
AU - Rasmussen, P. V.
AU - Graff, Claus
AU - Pietersen, Adrian
AU - Lind, Bent
AU - Struijk, Johannes J.
AU - Olesen, M. S.
AU - Haunsø, Stig
AU - Køber, Lars
AU - Svendsen, Jesper H.
AU - Holst, Anders G.
AU - Nielsen, Jonas B.
N1 - Copyright © 2015. Published by Elsevier Inc.
PY - 2016
Y1 - 2016
N2 - BACKGROUND: The electrocardiographic Tpeak-Tend interval is considered a novel risk marker of cardiac arrhythmias and cardiovascular death, however, results have so far been conflicting.OBJECTIVE: We aimed to investigate the association between this interval and the risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure, allowing for non-linear relationships.METHODS: From primary care, 138,404 individuals were included and categorized into 7 groups based on Tpeak-Tend interval. Cox regression models were used to describe the association between these groups and the risk of the selected outcomes.RESULTS: Compared with the reference groups (104-115 ms for all-cause mortality and 98-103 ms for all other outcomes), individuals with a Tpeak-Tend interval in lead V5 <5th percentile (58-77 ms) had hazard ratios of 1.29 (95% CI 1.21-1.38, p<0.001) for all-cause mortality, 1.31 (95% CI 1.15-1.50, p<0.001) for cardiovascular death, 1.18 (95% CI 1.06-1.32, p=0.003) for atrial fibrillation, and 1.52 (95% CI 1.33-1.74, p<0.001) for heart failure. Individuals with a Tpeak-Tend interval ≥95th percentile (116-140 ms) had hazard ratios of 1.15 (95% CI 1.08-1.23, p<0.001) for all-cause mortality, 1.30 (95% CI 1.15-1.47, p<0.001) for cardiovascular death, 1.09 (95% CI 0.99-1.22, p=0.088) for atrial fibrillation, and 1.28 (95% CI 1.12-1.46, p<0.001) for heart failure. Similar results were obtained for lead II and V2.CONCLUSIONS: We observed U-shaped associations between the Tpeak-Tend interval and risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure.
AB - BACKGROUND: The electrocardiographic Tpeak-Tend interval is considered a novel risk marker of cardiac arrhythmias and cardiovascular death, however, results have so far been conflicting.OBJECTIVE: We aimed to investigate the association between this interval and the risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure, allowing for non-linear relationships.METHODS: From primary care, 138,404 individuals were included and categorized into 7 groups based on Tpeak-Tend interval. Cox regression models were used to describe the association between these groups and the risk of the selected outcomes.RESULTS: Compared with the reference groups (104-115 ms for all-cause mortality and 98-103 ms for all other outcomes), individuals with a Tpeak-Tend interval in lead V5 <5th percentile (58-77 ms) had hazard ratios of 1.29 (95% CI 1.21-1.38, p<0.001) for all-cause mortality, 1.31 (95% CI 1.15-1.50, p<0.001) for cardiovascular death, 1.18 (95% CI 1.06-1.32, p=0.003) for atrial fibrillation, and 1.52 (95% CI 1.33-1.74, p<0.001) for heart failure. Individuals with a Tpeak-Tend interval ≥95th percentile (116-140 ms) had hazard ratios of 1.15 (95% CI 1.08-1.23, p<0.001) for all-cause mortality, 1.30 (95% CI 1.15-1.47, p<0.001) for cardiovascular death, 1.09 (95% CI 0.99-1.22, p=0.088) for atrial fibrillation, and 1.28 (95% CI 1.12-1.46, p<0.001) for heart failure. Similar results were obtained for lead II and V2.CONCLUSIONS: We observed U-shaped associations between the Tpeak-Tend interval and risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure.
U2 - 10.1016/j.hrthm.2015.12.027
DO - 10.1016/j.hrthm.2015.12.027
M3 - Journal article
C2 - 26707793
SN - 1547-5271
VL - 13
SP - 915
EP - 924
JO - Heart Rhythm
JF - Heart Rhythm
IS - 4
ER -