@article{0cac5aea08464fe0a7577fe7e289a275,
title = "Increasing incidence of ophthalmic lymphoma in Denmark from 1980 to 2005",
abstract = "PURPOSE: To evaluate patient characteristics and incidence of ophthalmic lymphoma in Denmark during the period 1980 to 2005. METHODS: All patients in Denmark with a diagnosis of ophthalmic lymphoma during the period 1980 to 2005 were retrieved from three different population-based registries. Specimens from all patients were collected and reclassified according to the World Health Organization (WHO) classification system. Incidence rates were calculated by using Poisson regression models. RESULTS: A total of 228 patients with a histologically verified diagnosis of ophthalmic lymphoma were included. There was an equal distribution of males and females. The most frequent lymphoma subtype was extranodal marginal zone B-cell lymphoma (MALT [mucosa-associated lymphoid tissue] lymphoma, 55.5%) and most cases were located in the orbit (56.8%). High-grade lymphoma subtypes were found more frequently in males than in females. Incidence rates were highly dependent on the patient's age. For all ages, a statistically significant annual average increase of 3.4% during the 26-year period was found. This increase was primarily due to a rise in the incidence of MALT lymphoma. CONCLUSIONS: In the Danish population ophthalmic lymphoma consists primarily of orbital MALT lymphoma. Although it is a rare disease in mostly elderly patients, the incidence of ophthalmic lymphoma is increasing at a rapid pace.",
keywords = "Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Denmark, Eye Neoplasms, Female, Humans, Immunophenotyping, Incidence, Lymphoma, Male, Middle Aged, Neoplasm Proteins, Sex Distribution, Tumor Markers, Biological",
author = "Sj{\"o}, {Lene D} and Elisabeth Ralfkiaer and Prause, {Jan U} and Petersen, {Jorgen H} and Jakob Madsen and Pedersen, {Niels T} and Steffen Heegaard",
year = "2008",
doi = "10.1167/iovs.08-1768",
language = "English",
volume = "49",
pages = "3283--8",
journal = "Investigative Ophthalmology & Visual Science",
issn = "0146-0404",
publisher = "ASSOC RESEARCH VISION OPHTHALMOLOGY INC",
}