TY - JOUR
T1 - Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model
AU - Jødal, Lars
AU - Jensen, S. B.
AU - Nielsen, Ole L
AU - Afzelius, Pia
AU - Borghammer, Per
AU - Alstrup, Aage K O
AU - Hansen, Søren B
N1 - ISI Document Delivery No.: FK6EK Times Cited: 0 Cited Reference Count: 48 Jodal, Lars Jensen, Svend B. Nielsen, Ole L. Afzelius, Pia Borghammer, Per Alstrup, Aage K. O. Hansen, Soren B. Danish Council for Independent Research, Technology and Production Sciences [0602-01911B (11-107077)] The authors are grateful for the support provided by the technical staff at Aarhus University Hospital, Aalborg University Hospital, and Copenhagen University. Vesa Oikonen is acknowledged for stimulating discussions and helping with the modelling software. This work was supported by the Danish Council for Independent Research, Technology and Production Sciences, Grant no. 0602-01911B (11-107077). 0 Wiley-hindawi London 1555-4317
PY - 2017
Y1 - 2017
N2 - Introduction. Positron emission tomography (PET) is increasingly applied for infection imaging using [F-18]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [F-18]FDG and three other PET tracers with relevance for infection imaging. Methods. A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [F-18]FDG, [Ga-68]Ga-citrate, [C-11]methionine, and/or [C-11]donepezil, along with blood sampling. For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer. Results. Irreversible uptake was found for [F-18]FDG and [Ga-68]Ga-citrate; reversible uptake was found for [C-11]methionine (two-tissue model) and [C-11]donepezil (one-tissue model). The uptake rate for [Ga-68]Ga-citrate was slow and diffusion-limited. For the other tracers, the uptake rate was primarily determined by perfusion (flow-limited uptake). Net uptake rate for [F-18]FDG and distribution volume for [C-11]methionine were significantly higher for infectious lesions than for correspondingly noninfected tissue. For [C-11]donepezil in pigs, labelled metabolite products appeared to be important for the analysis. Conclusions. The kinetics of the four studied tracers in infection was characterized. For clinical applications, [F-18]FDG remains the first-choice PET tracer. [C-11]methionine may have a potential for detecting soft tissue infections. [Ga-68]Ga-citrate and [C-11]donepezil were not found useful for imaging of osteomyelitis.
AB - Introduction. Positron emission tomography (PET) is increasingly applied for infection imaging using [F-18]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [F-18]FDG and three other PET tracers with relevance for infection imaging. Methods. A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [F-18]FDG, [Ga-68]Ga-citrate, [C-11]methionine, and/or [C-11]donepezil, along with blood sampling. For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer. Results. Irreversible uptake was found for [F-18]FDG and [Ga-68]Ga-citrate; reversible uptake was found for [C-11]methionine (two-tissue model) and [C-11]donepezil (one-tissue model). The uptake rate for [Ga-68]Ga-citrate was slow and diffusion-limited. For the other tracers, the uptake rate was primarily determined by perfusion (flow-limited uptake). Net uptake rate for [F-18]FDG and distribution volume for [C-11]methionine were significantly higher for infectious lesions than for correspondingly noninfected tissue. For [C-11]donepezil in pigs, labelled metabolite products appeared to be important for the analysis. Conclusions. The kinetics of the four studied tracers in infection was characterized. For clinical applications, [F-18]FDG remains the first-choice PET tracer. [C-11]methionine may have a potential for detecting soft tissue infections. [Ga-68]Ga-citrate and [C-11]donepezil were not found useful for imaging of osteomyelitis.
KW - positron-emission-tomography ga-68-citrate pet/ct graphical analysis dynamic pet c-11-methionine f-18-fdg binding acetylcholinesterase inflammation lesions Radiology, Nuclear Medicine & Medical Imaging
U2 - 10.1155/2017/9256858
DO - 10.1155/2017/9256858
M3 - Journal article
SN - 1555-4309
VL - 2017
JO - Contrast Media and Molecular Imaging
JF - Contrast Media and Molecular Imaging
M1 - 9256858
ER -