Abstract
OBJECTIVES: Postoperative new-onset atrial fibrillation (POAF) in cardiac surgery is associated with increased morbidity and mortality. Because n-3 polyunsaturated fatty acids (n-3 PUFA) have an antiarrhythmic effect, we hypothesized that a high content of marine n-3 PUFA in the atrial wall was associated with a reduced risk of POAF.
DESIGN: Venous blood and tissue from the right atrial appendage were obtained from 50 patients undergoing elective cardiac surgery. We determined the content of marine n-3 PUFA in atrial tissue and in plasma phospholipids using gas chromatography.
RESULTS: The mean age of the patients (results available from 49 patients) was 66.0±10.4years, and 22, 14, 10 and 3 patients underwent coronary artery bypass surgery, valve, combined or other cardiac surgery, respectively. Eighteen patients (36.7%) developed POAF. Concentrations of n-3 PUFA in the atrial wall and in plasma phospholipids did not predict the development of POAF, but there were significant correlations between marine n-3 PUFA in atrial tissue and plasma.
CONCLUSION: Levels of marine n-3 PUFA in the atrial wall was not associated with the risk of POAF following cardiac surgery, despite significant correlations of marine n-3 PUFA in the atrium and in plasma phospholipids.
Originalsprog | Engelsk |
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Tidsskrift | Vascular Pharmacology |
Vol/bind | 87 |
Sider (fra-til) | 70-75 |
Antal sider | 6 |
ISSN | 1537-1891 |
DOI | |
Status | Udgivet - 2016 |