TY - JOUR
T1 - Nanoreinforced hydrogels for tissue engineering
T2 - Biomaterials that are compatible with load-bearing and electroactive tissues
AU - Mehrali, Mehdi
AU - Thakur, Ashish
AU - Pennisi, Cristian Pablo
AU - Talebian, Sepehr
AU - Arpanaei, Ayyoob
AU - Nikkhah, Mehdi
AU - Dolatshahi-Pirouz, Alireza
N1 - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2017
Y1 - 2017
N2 - Given their highly porous nature and excellent water retention, hydrogel-based biomaterials can mimic critical properties of the native cellular environment. However, their potential to emulate the electromechanical milieu of native tissues or conform well with the curved topology of human organs needs to be further explored to address a broad range of physiological demands of the body. In this regard, the incorporation of nanomaterials within hydrogels has shown great promise, as a simple one-step approach, to generate multifunctional scaffolds with previously unattainable biological, mechanical, and electrical properties. Here, recent advances in the fabrication and application of nanocomposite hydrogels in tissue engineering applications are described, with specific attention toward skeletal and electroactive tissues, such as cardiac, nerve, bone, cartilage, and skeletal muscle. Additionally, some potential uses of nanoreinforced hydrogels within the emerging disciplines of cyborganics, bionics, and soft biorobotics are highlighted.
AB - Given their highly porous nature and excellent water retention, hydrogel-based biomaterials can mimic critical properties of the native cellular environment. However, their potential to emulate the electromechanical milieu of native tissues or conform well with the curved topology of human organs needs to be further explored to address a broad range of physiological demands of the body. In this regard, the incorporation of nanomaterials within hydrogels has shown great promise, as a simple one-step approach, to generate multifunctional scaffolds with previously unattainable biological, mechanical, and electrical properties. Here, recent advances in the fabrication and application of nanocomposite hydrogels in tissue engineering applications are described, with specific attention toward skeletal and electroactive tissues, such as cardiac, nerve, bone, cartilage, and skeletal muscle. Additionally, some potential uses of nanoreinforced hydrogels within the emerging disciplines of cyborganics, bionics, and soft biorobotics are highlighted.
U2 - 10.1002/adma.201603612
DO - 10.1002/adma.201603612
M3 - Journal article
C2 - 27966826
SN - 0935-9648
VL - 29
JO - Advanced Materials
JF - Advanced Materials
IS - 8
M1 - 1603612
ER -