Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium

Rasmus D Wollenberg; Søren S Donau; Thorbjørn T Nielsen; Jens L Sørensen; Henriette Giese; Reinhard Wimmer; Teis E Søndergaard

doi:10.1016/j.pestbp.2016.05.002

Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium

Rasmus D Wollenberg, Søren S Donau, Thorbjørn T Nielsen, Jens L Sørensen, Henriette Giese, Reinhard Wimmer, Teis E Søndergaard

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

Real-time imaging was used to study the effects of a novel Fusarium-specific cyanoacrylate fungicide (JS399-19) on growth and morphology of four Fusarium sp. This fungicide targets the motor domain of type I myosin. Fusarium graminearum PH-1, Fusarium solani f. sp. pisi 77-13-4, Fusarium avenaceum IBT8464, and Fusarium avenaceum 05001, which has a K216Q amino-acid substitution at the resistance-implicated site in its myosin type I motor domain, were analyzed. Real-time imaging shows that JS399-19 inhibits fungal growth but not to the extent previously reported. The fungicide causes the hypha to become entangled and unable to extend vertically. This implies that type I myosin in Fusarium is essential for hyphal and mycelia propagation. The K216Q substitution correlates with reduced susceptibility in F. avenaceum.

Originalsprog	Engelsk
Tidsskrift	Pesticide Biochemistry and Physiology
Vol/bind	134
Sider (fra-til)	24-30
Antal sider	7
ISSN	0048-3575
DOI	https://doi.org/10.1016/j.pestbp.2016.05.002
Status	Udgivet - nov. 2016

Adgang til dokumentet

10.1016/j.pestbp.2016.05.002

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Citationsformater

@article{06f99c3915394b55889a1b8957b1fbc3,

title = "Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium",

abstract = "Real-time imaging was used to study the effects of a novel Fusarium-specific cyanoacrylate fungicide (JS399-19) on growth and morphology of four Fusarium sp. This fungicide targets the motor domain of type I myosin. Fusarium graminearum PH-1, Fusarium solani f. sp. pisi 77-13-4, Fusarium avenaceum IBT8464, and Fusarium avenaceum 05001, which has a K216Q amino-acid substitution at the resistance-implicated site in its myosin type I motor domain, were analyzed. Real-time imaging shows that JS399-19 inhibits fungal growth but not to the extent previously reported. The fungicide causes the hypha to become entangled and unable to extend vertically. This implies that type I myosin in Fusarium is essential for hyphal and mycelia propagation. The K216Q substitution correlates with reduced susceptibility in F. avenaceum.",

author = "Wollenberg, {Rasmus D} and Donau, {S{\o}ren S} and Nielsen, {Thorbj{\o}rn T} and S{\o}rensen, {Jens L} and Henriette Giese and Reinhard Wimmer and S{\o}ndergaard, {Teis E}",

year = "2016",

month = nov,

doi = "10.1016/j.pestbp.2016.05.002",

language = "English",

volume = "134",

pages = "24--30",

journal = "Pesticide Biochemistry and Physiology",

issn = "0048-3575",

publisher = "Academic Press",

}

TY - JOUR

T1 - Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium

AU - Wollenberg, Rasmus D

AU - Donau, Søren S

AU - Nielsen, Thorbjørn T

AU - Sørensen, Jens L

AU - Giese, Henriette

AU - Wimmer, Reinhard

AU - Søndergaard, Teis E

PY - 2016/11

Y1 - 2016/11

N2 - Real-time imaging was used to study the effects of a novel Fusarium-specific cyanoacrylate fungicide (JS399-19) on growth and morphology of four Fusarium sp. This fungicide targets the motor domain of type I myosin. Fusarium graminearum PH-1, Fusarium solani f. sp. pisi 77-13-4, Fusarium avenaceum IBT8464, and Fusarium avenaceum 05001, which has a K216Q amino-acid substitution at the resistance-implicated site in its myosin type I motor domain, were analyzed. Real-time imaging shows that JS399-19 inhibits fungal growth but not to the extent previously reported. The fungicide causes the hypha to become entangled and unable to extend vertically. This implies that type I myosin in Fusarium is essential for hyphal and mycelia propagation. The K216Q substitution correlates with reduced susceptibility in F. avenaceum.

AB - Real-time imaging was used to study the effects of a novel Fusarium-specific cyanoacrylate fungicide (JS399-19) on growth and morphology of four Fusarium sp. This fungicide targets the motor domain of type I myosin. Fusarium graminearum PH-1, Fusarium solani f. sp. pisi 77-13-4, Fusarium avenaceum IBT8464, and Fusarium avenaceum 05001, which has a K216Q amino-acid substitution at the resistance-implicated site in its myosin type I motor domain, were analyzed. Real-time imaging shows that JS399-19 inhibits fungal growth but not to the extent previously reported. The fungicide causes the hypha to become entangled and unable to extend vertically. This implies that type I myosin in Fusarium is essential for hyphal and mycelia propagation. The K216Q substitution correlates with reduced susceptibility in F. avenaceum.

U2 - 10.1016/j.pestbp.2016.05.002

DO - 10.1016/j.pestbp.2016.05.002

M3 - Journal article

C2 - 27914536

SN - 0048-3575

VL - 134

SP - 24

EP - 30

JO - Pesticide Biochemistry and Physiology

JF - Pesticide Biochemistry and Physiology

ER -

Real-time imaging of the growth-inhibitory effect of JS399-19 on Fusarium

Abstract

Adgang til dokumentet

AUB Link

Fingeraftryk

Citationsformater