TY - JOUR
T1 - The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis
T2 - a cross-sectional study
AU - Riis, Robert Gabriel Coumine
AU - Gudbergsen, Henrik
AU - Simonsen, Ole
AU - Henriksen, Marius
AU - Musa Al-Mashkur, Nasir
AU - Eld, Mikkel
AU - Petersen, Kristian Kjær
AU - Kubassova, Olga
AU - Bay Jensen, Anne C
AU - Damm, Janus
AU - Bliddal, Henning
AU - Arendt-Nielsen, Lars
AU - Boesen, Mikael Ploug
N1 - Copyright © 2016. Published by Elsevier Ltd.
PY - 2017
Y1 - 2017
N2 - OBJECTIVES: To investigate the association between MRI, macroscopic and histological assessments of synovitis in end-stage knee osteoarthritis (KOA).METHODS: Synovitis of end-stage osteoarthritic knees was assessed using non-contrast-enhanced (CE), CE-MRI and dynamic-CE (DCE)-MRI prior to total knee replacement and correlated with microscopic and macroscopic assessments of synovitis obtained intraoperatively. Multiple bivariate correlations were used with a pre-specified threshold of 0.70 for significance. Also, multiple regression analyses with different subsets of MRI-variables as explanatory variables and the histology score as outcome variable were performed with the intention to find MRI-variables that best explain the variance in histological synovitis (i.e. highest R(2)). A stepped approach was taken starting with basic characteristics and non-CE MRI-variables (model 1), after which CE-MRI-variables were added (model 2) with the final model also including DCE-MRI-variables (model 3).RESULTS: 39 patients (56.4% women, mean age 68 years, Kellgren-Lawrence grade 4) had complete MRI and histological data. Only the DCE-MRI variable MExNvoxel (surrogate of the volume and degree of synovitis) and the macroscopic score showed correlations above the pre-specified threshold for acceptance with histological inflammation. The maximum R(2)-value obtained in Model 1 was R(2)=0.39. In Model 2, where the CE-MRI-variables were added, the highest R(2)=0.52. In Model 3, a four-variable model consisting of the gender, one CE-MRI and two DCE-MR-variables yielded a R(2)=0.71.CONCLUSION: DCE-MRI is correlated with histological synovitis in end-stage KOA and the combination of CE and DCE-MRI may be a useful, non-invasive tool in characterising synovitis in KOA.
AB - OBJECTIVES: To investigate the association between MRI, macroscopic and histological assessments of synovitis in end-stage knee osteoarthritis (KOA).METHODS: Synovitis of end-stage osteoarthritic knees was assessed using non-contrast-enhanced (CE), CE-MRI and dynamic-CE (DCE)-MRI prior to total knee replacement and correlated with microscopic and macroscopic assessments of synovitis obtained intraoperatively. Multiple bivariate correlations were used with a pre-specified threshold of 0.70 for significance. Also, multiple regression analyses with different subsets of MRI-variables as explanatory variables and the histology score as outcome variable were performed with the intention to find MRI-variables that best explain the variance in histological synovitis (i.e. highest R(2)). A stepped approach was taken starting with basic characteristics and non-CE MRI-variables (model 1), after which CE-MRI-variables were added (model 2) with the final model also including DCE-MRI-variables (model 3).RESULTS: 39 patients (56.4% women, mean age 68 years, Kellgren-Lawrence grade 4) had complete MRI and histological data. Only the DCE-MRI variable MExNvoxel (surrogate of the volume and degree of synovitis) and the macroscopic score showed correlations above the pre-specified threshold for acceptance with histological inflammation. The maximum R(2)-value obtained in Model 1 was R(2)=0.39. In Model 2, where the CE-MRI-variables were added, the highest R(2)=0.52. In Model 3, a four-variable model consisting of the gender, one CE-MRI and two DCE-MR-variables yielded a R(2)=0.71.CONCLUSION: DCE-MRI is correlated with histological synovitis in end-stage KOA and the combination of CE and DCE-MRI may be a useful, non-invasive tool in characterising synovitis in KOA.
U2 - 10.1016/j.joca.2016.10.006
DO - 10.1016/j.joca.2016.10.006
M3 - Journal article
C2 - 27737813
SN - 1063-4584
VL - 25
SP - 272
EP - 280
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 2
ER -