Abstract
In eight healthy individuals, the skin fold between the thumb and the forefinger was treated with 0.05% clobetasol propionate ointment under a hydrocolloid occlusive dressing. Using the atraumatic epicutaneous 133Xe wash-out technique on the outer 2 mm of the skin fold, covering the rest of the hand with a lead shield, we were able to monitor cutaneous blood flow. Blood flow was measured after 0, 10, 24, 48 and 72 h of treatment. During the first 10 h of treatment no significant change in blood flow was observed. However, compared to untreated tissue, cutaneous blood flow decreased significantly after a 24-h period (P less than 0.05). Furthermore a significant blood flow reduction from 0-48 (P less than 0.02) and from 0-72 h (P less than 0.01) was observed. Placebo did not decrease cutaneous blood flow, but a minor increase was demonstrated. The results of the present work demonstrate a long-lasting blood flow reducing effect of topical corticosteroid in normal human cutaneous tissue.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Clinical and Experimental Dermatology |
Vol/bind | 14 |
Udgave nummer | 3 |
Sider (fra-til) | 210-3 |
Antal sider | 4 |
ISSN | 0307-6938 |
DOI | |
Status | Udgivet - 1989 |
Udgivet eksternt | Ja |
Emneord
- Adrenal Cortex Hormones
- Adult
- Female
- Humans
- Male
- Regional Blood Flow
- Skin
- Time Factors
- Xenon Radioisotopes