TY - JOUR
T1 - Two-year outcome after biodegradable polymer sirolimus- and biolimus- eluting coronary stents
T2 - From the randomized SORT OUT VII trial
AU - Jensen, Lisette Okkels
AU - Maeng, Michael
AU - Raungaard, Bent
AU - Hansen, Knud Nørregaard
AU - Kahlert, Johnny
AU - Jensen, Svend Eggert
AU - Hansen, Henrik Steen
AU - Lassen, Jens Flensted
AU - Bøtker, Hans Erik
AU - Christiansen, Evald Høj
PY - 2018/1/20
Y1 - 2018/1/20
N2 - AIMS: The SORT OUT VII trial compared the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent with a slow polymer degradation and the thicker-strut stainless steel biolimus-eluting Nobori stent with a moderate-term polymer degradation in an all-comer patient population.METHODS AND RESULTS: The 2-year pre-specified endpoint target lesion failure did not differ significantly between the sirolimus-eluting stent: 6.7% and the biolimus-eluting stent: 7.0% (rate ratio (RR) 0.94, 95% confidence interval (CI) 0.70-1.28). Definite stent thrombosis were numerically lower in the sirolimus-eluting stent group (0.8%) compared to the biolimus-eluting stent group (1.4%) (RR 0.56, 95% CI 0.26-1.21), which largely was attributable to a lower risk of definite stent thrombosis within 1 year: 0.4% versus 1.2% (RR 0.33, 95% CI 0.12-0.92), whereas risk of very late definite stent thrombosis was similar in the two groups (0.4% versus 0.2%, RR 1.68, 95% CI 0.40-7.03).CONCLUSIONS: In an all-comer patient population, 2-year target lesions failure was similar for the sirolimus-eluting Orsiro stent and the biolimus-eluting Nobori stent.
AB - AIMS: The SORT OUT VII trial compared the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent with a slow polymer degradation and the thicker-strut stainless steel biolimus-eluting Nobori stent with a moderate-term polymer degradation in an all-comer patient population.METHODS AND RESULTS: The 2-year pre-specified endpoint target lesion failure did not differ significantly between the sirolimus-eluting stent: 6.7% and the biolimus-eluting stent: 7.0% (rate ratio (RR) 0.94, 95% confidence interval (CI) 0.70-1.28). Definite stent thrombosis were numerically lower in the sirolimus-eluting stent group (0.8%) compared to the biolimus-eluting stent group (1.4%) (RR 0.56, 95% CI 0.26-1.21), which largely was attributable to a lower risk of definite stent thrombosis within 1 year: 0.4% versus 1.2% (RR 0.33, 95% CI 0.12-0.92), whereas risk of very late definite stent thrombosis was similar in the two groups (0.4% versus 0.2%, RR 1.68, 95% CI 0.40-7.03).CONCLUSIONS: In an all-comer patient population, 2-year target lesions failure was similar for the sirolimus-eluting Orsiro stent and the biolimus-eluting Nobori stent.
KW - Journal Article
UR - http://www.scopus.com/inward/record.url?scp=85041675658&partnerID=8YFLogxK
U2 - 10.4244/EIJ-D-17-00731
DO - 10.4244/EIJ-D-17-00731
M3 - Journal article
C2 - 28870882
SN - 1774-024X
VL - 13
SP - 1587
EP - 1590
JO - EuroIntervention
JF - EuroIntervention
IS - 13
ER -