This paper gives indications to important factors that must be considered for effectiveness of the production control systems under uncertainty. Five key factors have been identified by the literature study. Production schedule generation and execution approach under uncertainty, information and communication technology, coordination and feedback, human factors and decision making, and measurement are the identified factors to be taken into account. Industrial interviews with three case companies, that are participating to the research program called The Norwegian Manufacturing Future (SFI NORMAN), have been carried out in order to gain practical insights as well as support and revise the findings by relevant empirical data. The limitations of this study appear due to the limited sample size of company interviews and therefore the results should be considered to provide preliminary insights.