Projects per year
Personal profile
Research profile
My research revolves around cancer immunotherapy in pre-clinical mouse tumor models, with focus on utilizing dendritic cells for therapy. My research is divided into two arms, one related to STING-targeted therapy and another related to therapeutic cancer vaccines.
STING has proven to be an interesting target for immunotherapy, especially as combination with immune checkpoint inhibitors (ICI). My current aim is to use cholesterol interfering drugs, to prime the STING-pathway, thus making it more susceptible to stimulation during immunotherapy. In addition, I investigate the possible use of caspase-inhibition, as a mean to activate or prime the STING-pathway.
Cancer vaccines holds the potential to aid antigen-presentation and T cell activation during ICI treatment. We have generated a small recombinant protein vaccine, capable of maturing dendritic cells, thereby inducing activation of tumor-specific T cells. The vaccine carries a nucleotide adjuvant capable of activating dendritic cells through the cGAS/STING-pathway or the TLR3-pathway.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Medicine
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Collaborations from the last five years
Projects
- 4 Active
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EPIC-1: A phase II Study of Electroporation Potentiated Immunotherapy in Liver Metastatic Pancreatic Cancer
Flak, R. V., Ladekarl, M., Poulsen, L. Ø., Thorlacius-Ussing, O., Stender, M. T., Detlefsen, S., Agger, R., Kofod-Olsen, E. & Wanders, A.
01/01/2021 → 31/12/2025
Project: Research
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Inflammatory cell death and dendritic cell activation in the tumor microenvironment
01/09/2017 → …
Project: Research
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Research output
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Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds
Zhang, B-C., Laursen, M. F., Hu, L., Hazrati, H., Narita, R., Jensen, L. S., Hansen, A. S., Huang, J., Zhang, Y., Ding, X., Muyesier, M., Nilsson, E., Banasik, A., Zeiler, C., Mogensen, T. H., Etzerodt, A., Agger, R., Johannsen, M., Kofod-Olsen, E., Paludan, S. R., & 1 others , 29 Mar 2024, In: Nature Communications. 15, 1, 2760.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
Activation of dendritic cells by targeted DNA: a potential addition to the armamentarium for anti-cancer immunotherapy
Fyrstenberg Laursen, M., Kofod-Olsen, E. & Agger, R., Nov 2019, In: Cancer Immunology, Immunotherapy. 68, 11, p. 1875-1880 6 p.Research output: Contribution to journal › Review article › peer-review
10 Citations (Scopus) -
Novel nucleotide-packaging vaccine delivers antigen and poly(I:C) to dendritic cells and generate a potent antibody response in vivo
Bruun, N., Laursen, M. F., Carmelo, R., Christensen, E., Jensen, T. S., Christiansen, G., Birkelund, S., Agger, R. & Kofod-Olsen, E., 19 Apr 2024, In: Vaccine. 42, 11, p. 2909-2918 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
CD11c-targeted delivery of DNA to dendritic cells leads to cGAS- and STING-dependent maturation
Laursen, M. F., Christensen, E., Degn, L. L. T., Jønsson, K., Jakobsen, M. R., Agger, R. & Kofod-Olsen, E., 2018, In: Journal of Immunotherapy. 41, 1, p. 9-18 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus) -
Development of a dendritic cell-targeting vaccine against cancer
Bruun, N., Laursen, M. F., Kofod-Olsen, E. & Agger, R., 2022.Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review
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Aarhus University (External organisation)
Emil Kofod-Olsen (Member)
18 Nov 2022Activity: Memberships › Membership of review committee
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Aarhus University (External organisation)
Emil Kofod-Olsen (Member)
17 Nov 2022Activity: Memberships › Membership of review committee
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Aarhus University (External organisation)
Emil Kofod-Olsen (Member)
1 Oct 2022Activity: Memberships › Membership of review committee
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Technical University of Denmark (External organisation)
Emil Kofod-Olsen (Member)
1 Sept 2022Activity: Memberships › Membership of review committee
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Aarhus University (External organisation)
Emil Kofod-Olsen (Member)
30 May 2022Activity: Memberships › Membership of review committee
Press/Media
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Knæk Cancer på tur til fire danske byer
11/10/2017
4 items of Media coverage
Press/Media: Press / Media