Activities per year
Project Details
Description
Infection is the most common cause of death in early life, especially for newborns and can be reduced by immunization but insufficient knowledge of how vaccines protect the very young limits their optimal use. To gain insight into how vaccines induce protection of the most vulnerable, this National Institutes of Health (NIH)/National Institute of Allergy & Infectious Diseases (NIAID)-funded Human Immunology Project Consortium (HIPC) study, based at Boston Children's Hospital and conducted by the Expanded Program on Immunization Consortium (EPIC), employs two novel approaches studying newborn responses to hepatitis B vaccine (HBV): (a) systems biology that uses technologies which comprehensively measure global changes in molecules such as transcriptomics (RNA) and proteomics (proteins), as well as cell composition of the blood and (b) use of human newborn blood components, collected prior to immunization, to model vaccine responses in vitro (outside the body). Characterizing vaccine-induced molecular patterns ("signatures") that correspond to vaccine-mediated protection will accelerate development and optimization of vaccines against early life infections of major global health importance
(https://clinicaltrials.gov/ct2/show/NCT03246230).
(https://clinicaltrials.gov/ct2/show/NCT03246230).
Layman's description
Improve our understanding of our immune system and vaccinations, with a focus on the developing immune system in newborns.
Acronym | EPIC-HIPC |
---|---|
Status | Finished |
Effective start/end date | 01/01/2016 → 01/01/2022 |
Collaborative partners
- Boston Children's Hospital
Funding
- Lundbeck Foundation: DKK18,580.00
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Activities
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EPIC-HIPC manuscript committee (External organisation)
Tue Bjerg Bennike (Chairperson)
1 Apr 2020 → …Activity: Memberships › Membership of committees, commissions, boards, councils, associations, organisations, or similar
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Preparing for life: Plasma proteome changes and immune system development during the first week of human life
Tue Bjerg Bennike (Lecturer)
3 Dec 2019Activity: Talks and presentations › Conference presentations
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Ontogeny of the plasma proteome across the first week of human life
Tue Bjerg Bennike (Lecturer)
18 Oct 2019Activity: Talks and presentations › Conference presentations
Research output
- 1 Poster
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Ontogeny of the plasma proteome during the first week of life
Bennike, T. B., Fatou, B., Wurie, Z., Idoko, O. T., Kampmann, B., Levy, O. & Steen, H., 27 Mar 2019.Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review
Press/Media
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How Do Our Immune Systems Develop in the First Days of Life?
22/10/2020
6 items of Media coverage
Press/Media: Press / Media
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Weekly highlight from Precision Vaccines Program
05/07/2019
1 item of Media coverage
Press/Media: Press / Media