A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models

Andreas Nørgaard Glud; Johannes Bech; Laura Tvilling; Hamed Zaer; Dariusz Orlowski; Lise Moberg Fitting; Dora Ziedler; Michael Geneser; Ryan Sangill; Aage Kristian Olsen Alstrup; Carsten Reidies Bjarkam; Jens Christian Hedemann Sørensen

doi:10.1016/j.jneumeth.2017.04.017

A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models

Andreas Nørgaard Glud, Johannes Bech, Laura Tvilling, Hamed Zaer, Dariusz Orlowski, Lise Moberg Fitting, Dora Ziedler, Michael Geneser, Ryan Sangill, Aage Kristian Olsen Alstrup, Carsten Reidies Bjarkam, Jens Christian Hedemann Sørensen

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.

NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.

RESULTS: Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space.

COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.

CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.

Original language	English
Journal	Journal of Neuroscience Methods
Volume	285
Pages (from-to)	45-48
Number of pages	4
ISSN	0165-0270
DOIs	https://doi.org/10.1016/j.jneumeth.2017.04.017
Publication status	Published - 2017

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10.1016/j.jneumeth.2017.04.017

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@article{5296472326f44ab0aef3690d7fdeca94,

title = "A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models",

abstract = "BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.RESULTS: Both types of fiducial markers were clearly visible on the MR{\'I}s. This allows high precision in the stereotaxic space.COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.",

keywords = "Journal Article",

author = "Glud, {Andreas N{\o}rgaard} and Johannes Bech and Laura Tvilling and Hamed Zaer and Dariusz Orlowski and Fitting, {Lise Moberg} and Dora Ziedler and Michael Geneser and Ryan Sangill and Alstrup, {Aage Kristian Olsen} and Bjarkam, {Carsten Reidies} and S{\o}rensen, {Jens Christian Hedemann}",

note = "Copyright {\textcopyright} 2017. Published by Elsevier B.V.",

year = "2017",

doi = "10.1016/j.jneumeth.2017.04.017",

language = "English",

volume = "285",

pages = "45--48",

journal = "Journal of Neuroscience Methods",

issn = "0165-0270",

publisher = "Elsevier",

}

TY - JOUR

T1 - A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models

AU - Glud, Andreas Nørgaard

AU - Bech, Johannes

AU - Tvilling, Laura

AU - Zaer, Hamed

AU - Orlowski, Dariusz

AU - Fitting, Lise Moberg

AU - Ziedler, Dora

AU - Geneser, Michael

AU - Sangill, Ryan

AU - Alstrup, Aage Kristian Olsen

AU - Bjarkam, Carsten Reidies

AU - Sørensen, Jens Christian Hedemann

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.RESULTS: Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space.COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.

AB - BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.RESULTS: Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space.COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.

KW - Journal Article

U2 - 10.1016/j.jneumeth.2017.04.017

DO - 10.1016/j.jneumeth.2017.04.017

M3 - Journal article

C2 - 28472679

SN - 0165-0270

VL - 285

SP - 45

EP - 48

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

ER -

A fiducial skull marker for precise MRI-based stereotaxic surgery in large animal models

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