TY - JOUR
T1 - A meta-analysis of executive dysfunction in patients with schizophrenia
T2 - Different degree of impairment in the ecological subdomains of the Behavioural Assessment of the Dysexecutive Syndrome
AU - Thai, Maria Lotus
AU - Andreassen, Anna Krogh
AU - Bliksted, Vibeke
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - We performed meta-analyses of studies using the 6 subtests of the neuropsychological test battery, the Behavioural Assessment of the Dysexecutive Syndrome (BADS), in order to assess and compare subdomains of executive dysfunction in stable phase patients with schizophrenia relative to healthy controls. The meta-analyses were performed according to the PRISMA statement. A systematic literature search was performed yielding 10 studies for inclusion (NSCH = 375; NHC = 541). Meta-analyses were done using Stata IC 14. Due to large heterogeneity and the few number of studies a random-effects model was used along with Hedges' g. Results showed that relative to healthy controls, patients with schizophrenia overall performed significantly worse in all subtests of BADS. However, moderate effect sizes were seen with regard to temporal estimation and strategy-forming, while very large effect sizes were seen regarding complex forward planning, inhibition, cognitive flexibility and novel problem solving. The findings from this meta-analysis demonstrate a significant difference between patients with (primarily) longer lasting schizophrenia and healthy control subjects on all subdomains of executive functions (EF). But some aspects of EF seem to be more severely affected than others. Future research and clinical interventions need to differentiate between subdomains of EF.
AB - We performed meta-analyses of studies using the 6 subtests of the neuropsychological test battery, the Behavioural Assessment of the Dysexecutive Syndrome (BADS), in order to assess and compare subdomains of executive dysfunction in stable phase patients with schizophrenia relative to healthy controls. The meta-analyses were performed according to the PRISMA statement. A systematic literature search was performed yielding 10 studies for inclusion (NSCH = 375; NHC = 541). Meta-analyses were done using Stata IC 14. Due to large heterogeneity and the few number of studies a random-effects model was used along with Hedges' g. Results showed that relative to healthy controls, patients with schizophrenia overall performed significantly worse in all subtests of BADS. However, moderate effect sizes were seen with regard to temporal estimation and strategy-forming, while very large effect sizes were seen regarding complex forward planning, inhibition, cognitive flexibility and novel problem solving. The findings from this meta-analysis demonstrate a significant difference between patients with (primarily) longer lasting schizophrenia and healthy control subjects on all subdomains of executive functions (EF). But some aspects of EF seem to be more severely affected than others. Future research and clinical interventions need to differentiate between subdomains of EF.
KW - Cognitive flexibility
KW - Inhibition
KW - Organizing
KW - Planning
KW - Problem solving
KW - Schizophrenia/complications
KW - Cognitive Dysfunction/etiology
KW - Humans
KW - Executive Function/physiology
KW - Neuropsychological Tests/statistics & numerical data
UR - http://www.scopus.com/inward/record.url?scp=85058959042&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2018.12.088
DO - 10.1016/j.psychres.2018.12.088
M3 - Review article
C2 - 30590277
SN - 0165-1781
VL - 272
SP - 230
EP - 236
JO - Psychiatry Research
JF - Psychiatry Research
ER -