Broadband diffuse optical characterization of elastin for biomedical applications

Sanathana Konugolu Venkata Sekar, Joo Sin Beh, Andrea Farina, Alberto Dalla Mora, Antonio Pifferi, Paola Taroni

Research output: Contribution to journalJournal articleResearchpeer-review

12 Citations (Scopus)

Abstract

Elastin is a key structural protein of dynamic connective tissues widely found in the extracellular matrix of skin, arteries, lungs and ligaments. It is responsible for a range of diseases related to aging of biological tissues. The optical characterization of elastin can open new opportunities for its investigation in biomedical studies. In this work, we present the absorption spectra of elastin using a broadband (550-1350nm) diffuse optical spectrometer. Distortions caused by fluorescence and finite bandwidth of the laser source on estimated absorption were effectively accounted for in measurements and data analysis and compensated. A comprehensive summary and comparison between collagen and elastin is presented, highlighting distinct features for its accurate quantification in biological applications.

Original languageEnglish
JournalBiophysical Chemistry
Volume229
Pages (from-to)130-134
ISSN0301-4622
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Animals
  • Cattle
  • Elastin
  • Extracellular Matrix
  • Spectrophotometry, Infrared
  • Journal Article

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