Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities

L P Diederichsen; J A Simonsen; A C Diederichsen; Svend Hvidsten; M Hougaard; P Junker; K Søndergaard; I E Lundberg; N Tvede; Ncf Sandgaard; A F Christensen; L Dreyer; S Kay; K S Eskerud; H Petersen; L Ejstrup; Søren Jacobsen

doi:10.1002/acr.22772

Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities

L P Diederichsen, J A Simonsen, A C Diederichsen, Svend Hvidsten, M Hougaard, P Junker, K Søndergaard, I E Lundberg, N Tvede, Ncf Sandgaard, A F Christensen, L Dreyer, S Kay, K S Eskerud, H Petersen, L Ejstrup, Søren Jacobsen

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

Abstract

Objectives Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies (IIM). The study objective was in a controlled setting to describe cardiac abnormalities by non-invasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction. Methods In a cross-sectional study, 76 patients with PM/DM and 48 matched healthy controls (HC) were assessed by serum levels of cardiac troponin-I (TnI), electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging (TDI) and quantitative cardiac (99m) technetium pyrophosphate ((99m) Tc-PYP) scintigraphy. Results Compared to HCs, patients with PM/DM more frequently had left ventricular diastolic dysfunction (LVDD) (12% vs. 0%, P = 0.02) and longer QRS and QTc intervals (P = 0.007 and P

Original language	English
Journal	Arthritis Care & Research
Volume	68
Issue number	7
Pages (from-to)	1012-1020
Number of pages	9
ISSN	2151-464X
DOIs	https://doi.org/10.1002/acr.22772
Publication status	Published - 2016
Externally published	Yes

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Diederichsen, L. P., Simonsen, J. A., Diederichsen, A. C., Hvidsten, S., Hougaard, M., Junker, P., Søndergaard, K., Lundberg, I. E., Tvede, N., Sandgaard, N., Christensen, A. F., Dreyer, L., Kay, S., Eskerud, K. S., Petersen, H., Ejstrup, L., & Jacobsen, S. (2016). Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities. Arthritis Care & Research, 68(7), 1012-1020. https://doi.org/10.1002/acr.22772

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title = "Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities",

abstract = "Objectives Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies (IIM). The study objective was in a controlled setting to describe cardiac abnormalities by non-invasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction. Methods In a cross-sectional study, 76 patients with PM/DM and 48 matched healthy controls (HC) were assessed by serum levels of cardiac troponin-I (TnI), electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging (TDI) and quantitative cardiac (99m) technetium pyrophosphate ((99m) Tc-PYP) scintigraphy. Results Compared to HCs, patients with PM/DM more frequently had left ventricular diastolic dysfunction (LVDD) (12% vs. 0%, P = 0.02) and longer QRS and QTc intervals (P = 0.007 and P ",

author = "Diederichsen, {L P} and Simonsen, {J A} and Diederichsen, {A C} and Svend Hvidsten and M Hougaard and P Junker and K S{\o}ndergaard and Lundberg, {I E} and N Tvede and Ncf Sandgaard and Christensen, {A F} and L Dreyer and S Kay and Eskerud, {K S} and H Petersen and L Ejstrup and S{\o}ren Jacobsen",

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doi = "10.1002/acr.22772",

language = "English",

volume = "68",

pages = "1012--1020",

journal = "Arthritis Care & Research",

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Diederichsen, LP, Simonsen, JA, Diederichsen, AC, Hvidsten, S, Hougaard, M, Junker, P, Søndergaard, K, Lundberg, IE, Tvede, N, Sandgaard, N, Christensen, AF, Dreyer, L, Kay, S, Eskerud, KS, Petersen, H, Ejstrup, L & Jacobsen, S 2016, 'Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities', Arthritis Care & Research, vol. 68, no. 7, pp. 1012-1020. https://doi.org/10.1002/acr.22772

TY - JOUR

T1 - Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities

AU - Diederichsen, L P

AU - Simonsen, J A

AU - Diederichsen, A C

AU - Hvidsten, Svend

AU - Hougaard, M

AU - Junker, P

AU - Søndergaard, K

AU - Lundberg, I E

AU - Tvede, N

AU - Sandgaard, Ncf

AU - Christensen, A F

AU - Dreyer, L

AU - Kay, S

AU - Eskerud, K S

AU - Petersen, H

AU - Ejstrup, L

AU - Jacobsen, Søren

PY - 2016

Y1 - 2016

N2 - Objectives Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies (IIM). The study objective was in a controlled setting to describe cardiac abnormalities by non-invasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction. Methods In a cross-sectional study, 76 patients with PM/DM and 48 matched healthy controls (HC) were assessed by serum levels of cardiac troponin-I (TnI), electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging (TDI) and quantitative cardiac (99m) technetium pyrophosphate ((99m) Tc-PYP) scintigraphy. Results Compared to HCs, patients with PM/DM more frequently had left ventricular diastolic dysfunction (LVDD) (12% vs. 0%, P = 0.02) and longer QRS and QTc intervals (P = 0.007 and P

AB - Objectives Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies (IIM). The study objective was in a controlled setting to describe cardiac abnormalities by non-invasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction. Methods In a cross-sectional study, 76 patients with PM/DM and 48 matched healthy controls (HC) were assessed by serum levels of cardiac troponin-I (TnI), electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging (TDI) and quantitative cardiac (99m) technetium pyrophosphate ((99m) Tc-PYP) scintigraphy. Results Compared to HCs, patients with PM/DM more frequently had left ventricular diastolic dysfunction (LVDD) (12% vs. 0%, P = 0.02) and longer QRS and QTc intervals (P = 0.007 and P

U2 - 10.1002/acr.22772

DO - 10.1002/acr.22772

M3 - Journal article

SN - 2151-464X

VL - 68

SP - 1012

EP - 1020

JO - Arthritis Care & Research

JF - Arthritis Care & Research

IS - 7

ER -