Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis

Andreas Westh Vilsbøll; Jakob Munk Mouritsen; Line Park Jensen; Nikolaj Bødker; Annette Willemoes Holst; Cristian Pablo Pennisi; Lars Holger Ehlers

doi:10.2217/rme-2017-0124

Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis

Andreas Westh Vilsbøll, Jakob Munk Mouritsen, Line Park Jensen, Nikolaj Bødker, Annette Willemoes Holst, Cristian Pablo Pennisi, Lars Holger Ehlers

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

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Abstract

Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

Translated title of the contribution	Cellebaseret terapi til behandling af kvindelig stressininkontinens: en tidlig omkostningseffektivitetsanalyse
Original language	English
Journal	Regenerative Medicine
Volume	13
Issue number	3
Pages (from-to)	321-330
Number of pages	10
ISSN	1746-0751
DOIs	https://doi.org/10.2217/rme-2017-0124
Publication status	Published - 1 May 2018

Keywords

cell- and tissue-based therapy
economic analysis
healthcare costs
incremental cost-effectiveness ratio
midurethral slings
myoblast transplantation
stress urinary incontinence

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10.2217/rme-2017-0124Licence: CC BY-NC-ND 4.0

Open Access articleFinal published version, 524 KBLicence: CC BY-NC-ND 4.0

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title = "Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis",

abstract = "Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.",

keywords = "cell- and tissue-based therapy, economic analysis, healthcare costs, incremental cost-effectiveness ratio, midurethral slings, myoblast transplantation, stress urinary incontinence",

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T1 - Cell-based therapy for the treatment of female stress urinary incontinence

T2 - an early cost–effectiveness analysis

AU - Vilsbøll, Andreas Westh

AU - Mouritsen, Jakob Munk

AU - Jensen, Line Park

AU - Bødker, Nikolaj

AU - Holst, Annette Willemoes

AU - Pennisi, Cristian Pablo

AU - Ehlers, Lars Holger

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

AB - Aim: To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence. Methods: Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions. Results & conclusion: In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

KW - cell- and tissue-based therapy

KW - economic analysis

KW - healthcare costs

KW - incremental cost-effectiveness ratio

KW - midurethral slings

KW - myoblast transplantation

KW - stress urinary incontinence

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JF - Regenerative Medicine

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Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis

Abstract

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Cite this

Cell-based therapy for the treatment of female stress urinary incontinence: an early cost–effectiveness analysis

Abstract

Keywords

Access to Document

AUB Link

Other files and links

Fingerprint

Activities

Managament Board of the COST Action BM1209 (External organisation)

Cite this