Changes in renal function after catheter ablation of atrial fibrillation are associated with CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences

Jelena Kornej; Gerhard Hindricks; Amitava Banerjee; Arash Arya; Philipp Sommer; Sascha Rolf; Daniela Husser; Gregory Y H Lip; Andreas Bollmann

doi:10.1136/heartjnl-2014-306013

Changes in renal function after catheter ablation of atrial fibrillation are associated with CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences

Jelena Kornej, Gerhard Hindricks, Amitava Banerjee, Arash Arya, Philipp Sommer, Sascha Rolf, Daniela Husser, Gregory Y H Lip, Andreas Bollmann

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

BACKGROUND: Renal impairment is associated with poor prognosis in the setting of atrial fibrillation (AF). While AF catheter ablation is an effective treatment modality for AF burden reduction and improvement of symptoms, changes in renal function after catheter ablation and their association with rhythm outcome have not been studied in a large contemporary AF ablation cohort.

OBJECTIVE: To determine the association between CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences with changes in renal function following AF catheter ablation.

METHODS: Estimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation at baseline and during follow-up in 783 patients undergoing de novo AF catheter ablation. Complete rhythm follow-up was achieved in 626 patients (80%) using serial 7-day Holter ECG.

RESULTS: The study population (n=783, 61±10 years, 64% men, 57% paroxysmal AF) was followed up at median 20 (IQR 12-27) months. Baseline eGFR correlated with CHADS2 (β=-0.258, p<0.001) and CHA2DS2-VASc scores (β=-0.434, p<0.001). On multivariable analyses, eGFR changes were associated with AF recurrences (B=-0.136, p=0.014), CHADS2 (B=-0.062, p=0.035) and CHA2DS2-VASc scores (B=-0.057, p=0.003).

CONCLUSIONS: In patients after AF catheter ablation, eGFR changes during mid-term follow-up are associated with AF recurrences, CHADS2 and CHA2DS2-VASc scores.

Original language	English
Journal	Heart
Volume	101
Issue number	2
Pages (from-to)	126-31
Number of pages	6
ISSN	1355-6037
DOIs	https://doi.org/10.1136/heartjnl-2014-306013
Publication status	Published - Jan 2015
Externally published	Yes

Keywords

Aged
Atrial Fibrillation
Catheter Ablation
Decision Support Techniques
Electrocardiography, Ambulatory
Female
Follow-Up Studies
Germany
Glomerular Filtration Rate
Humans
Male
Middle Aged
Postoperative Complications
Predictive Value of Tests
Recurrence
Renal Insufficiency
Risk Assessment
Risk Factors
Treatment Outcome

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@article{c329f64bc07c4f689bedbfd379165feb,

title = "Changes in renal function after catheter ablation of atrial fibrillation are associated with CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences",

abstract = "BACKGROUND: Renal impairment is associated with poor prognosis in the setting of atrial fibrillation (AF). While AF catheter ablation is an effective treatment modality for AF burden reduction and improvement of symptoms, changes in renal function after catheter ablation and their association with rhythm outcome have not been studied in a large contemporary AF ablation cohort.OBJECTIVE: To determine the association between CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences with changes in renal function following AF catheter ablation.METHODS: Estimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation at baseline and during follow-up in 783 patients undergoing de novo AF catheter ablation. Complete rhythm follow-up was achieved in 626 patients (80%) using serial 7-day Holter ECG.RESULTS: The study population (n=783, 61±10 years, 64% men, 57% paroxysmal AF) was followed up at median 20 (IQR 12-27) months. Baseline eGFR correlated with CHADS2 (β=-0.258, p<0.001) and CHA2DS2-VASc scores (β=-0.434, p<0.001). On multivariable analyses, eGFR changes were associated with AF recurrences (B=-0.136, p=0.014), CHADS2 (B=-0.062, p=0.035) and CHA2DS2-VASc scores (B=-0.057, p=0.003).CONCLUSIONS: In patients after AF catheter ablation, eGFR changes during mid-term follow-up are associated with AF recurrences, CHADS2 and CHA2DS2-VASc scores.",

keywords = "Aged, Atrial Fibrillation, Catheter Ablation, Decision Support Techniques, Electrocardiography, Ambulatory, Female, Follow-Up Studies, Germany, Glomerular Filtration Rate, Humans, Male, Middle Aged, Postoperative Complications, Predictive Value of Tests, Recurrence, Renal Insufficiency, Risk Assessment, Risk Factors, Treatment Outcome",

author = "Jelena Kornej and Gerhard Hindricks and Amitava Banerjee and Arash Arya and Philipp Sommer and Sascha Rolf and Daniela Husser and Lip, {Gregory Y H} and Andreas Bollmann",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2015",

month = jan,

doi = "10.1136/heartjnl-2014-306013",

language = "English",

volume = "101",

pages = "126--31",

journal = "Heart",

issn = "1355-6037",

publisher = "B M J Group",

number = "2",

}

TY - JOUR

T1 - Changes in renal function after catheter ablation of atrial fibrillation are associated with CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences

AU - Kornej, Jelena

AU - Hindricks, Gerhard

AU - Banerjee, Amitava

AU - Arya, Arash

AU - Sommer, Philipp

AU - Rolf, Sascha

AU - Husser, Daniela

AU - Lip, Gregory Y H

AU - Bollmann, Andreas

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/1

Y1 - 2015/1

N2 - BACKGROUND: Renal impairment is associated with poor prognosis in the setting of atrial fibrillation (AF). While AF catheter ablation is an effective treatment modality for AF burden reduction and improvement of symptoms, changes in renal function after catheter ablation and their association with rhythm outcome have not been studied in a large contemporary AF ablation cohort.OBJECTIVE: To determine the association between CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences with changes in renal function following AF catheter ablation.METHODS: Estimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation at baseline and during follow-up in 783 patients undergoing de novo AF catheter ablation. Complete rhythm follow-up was achieved in 626 patients (80%) using serial 7-day Holter ECG.RESULTS: The study population (n=783, 61±10 years, 64% men, 57% paroxysmal AF) was followed up at median 20 (IQR 12-27) months. Baseline eGFR correlated with CHADS2 (β=-0.258, p<0.001) and CHA2DS2-VASc scores (β=-0.434, p<0.001). On multivariable analyses, eGFR changes were associated with AF recurrences (B=-0.136, p=0.014), CHADS2 (B=-0.062, p=0.035) and CHA2DS2-VASc scores (B=-0.057, p=0.003).CONCLUSIONS: In patients after AF catheter ablation, eGFR changes during mid-term follow-up are associated with AF recurrences, CHADS2 and CHA2DS2-VASc scores.

AB - BACKGROUND: Renal impairment is associated with poor prognosis in the setting of atrial fibrillation (AF). While AF catheter ablation is an effective treatment modality for AF burden reduction and improvement of symptoms, changes in renal function after catheter ablation and their association with rhythm outcome have not been studied in a large contemporary AF ablation cohort.OBJECTIVE: To determine the association between CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences with changes in renal function following AF catheter ablation.METHODS: Estimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation at baseline and during follow-up in 783 patients undergoing de novo AF catheter ablation. Complete rhythm follow-up was achieved in 626 patients (80%) using serial 7-day Holter ECG.RESULTS: The study population (n=783, 61±10 years, 64% men, 57% paroxysmal AF) was followed up at median 20 (IQR 12-27) months. Baseline eGFR correlated with CHADS2 (β=-0.258, p<0.001) and CHA2DS2-VASc scores (β=-0.434, p<0.001). On multivariable analyses, eGFR changes were associated with AF recurrences (B=-0.136, p=0.014), CHADS2 (B=-0.062, p=0.035) and CHA2DS2-VASc scores (B=-0.057, p=0.003).CONCLUSIONS: In patients after AF catheter ablation, eGFR changes during mid-term follow-up are associated with AF recurrences, CHADS2 and CHA2DS2-VASc scores.

KW - Aged

KW - Atrial Fibrillation

KW - Catheter Ablation

KW - Decision Support Techniques

KW - Electrocardiography, Ambulatory

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Glomerular Filtration Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Predictive Value of Tests

KW - Recurrence

KW - Renal Insufficiency

KW - Risk Assessment

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.1136/heartjnl-2014-306013

DO - 10.1136/heartjnl-2014-306013

M3 - Journal article

C2 - 25281600

SN - 1355-6037

VL - 101

SP - 126

EP - 131

JO - Heart

JF - Heart

IS - 2

ER -

Changes in renal function after catheter ablation of atrial fibrillation are associated with CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences

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Keywords

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