Research output per year
Research output per year
Masashi Izumi, Kristian Kjær Petersen, Mogens Berg Laursen, Lars Arendt-Nielsen, Thomas Graven-Nielsen
Research output: Contribution to journal › Journal article › Research › peer-review
Widespread hyperalgesia has been found in patients with painful hip osteoarthritis (OA) which can be normalized after total hip arthroplasty (THA) if patients have no residual postoperative pain. This study characterized the preoperative somatosensory profiles and provided possible interpretation of underlying pain mechanisms that might influence the development of postoperative pain. Forty hip OA patients with unilateral pain were assessed before and 6 weeks post-THA and compared with forty asymptomatic control subjects. Hip pain intensity at rest and while walking was assessed on a visual analogue scale (VAS). Bilateral cuff algometry from the thighs were used to assess the cuff pressure pain thresholds (cPPT), pressure values at VAS scores equal with 6 cm (PVAS6), cuff pressure tolerance (cPTT), and temporal summation of pain (TSP) quantified by an increase in VAS scores to repeated phasic cuff stimulations. Correlations between hip pain VAS post-THA and preoperative QST results were analyzed. Post-THA hip pain VAS scores decreased (P<0.05) compared to pre-THA. The cPPT, PVAS6, and cPTT were significantly lower bilaterally in both pre-THA and post-THA patients compared with controls (P<0.05). TSP was facilitated bilaterally in pre-THA patients compared with controls and normalized following THA in postoperative pain-free patients (P<0.05). Postoperative hip pain VAS scores correlated with preoperative ipsilateral TSP (r=0.44, P<0.05). Bilateral pressure pain hypersensitivity and facilitated TSP were demonstrated in preoperative hip OA patients. Although persistent postoperative pain is known as multifactorial, greater preoperative TSP was associated with greater pain and less reduction in pain after THA.
Original language | English |
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Journal | Pain |
Volume | 158 |
Issue number | 2 |
Pages (from-to) | 323-332 |
ISSN | 0304-3959 |
DOIs | |
Publication status | Published - 2017 |
Research output: Book/Report › Doctoral thesis