TY - JOUR
T1 - Allelic drop-out probabilities estimated by logistic regression
T2 - Further considerations and practical implementation
AU - Tvedebrink, Torben
AU - Eriksen, Poul Svante
AU - Asplund, Maria
AU - Mogensen, Helle Smidt
AU - Morling, Niels
PY - 2012
Y1 - 2012
N2 - We discuss the model for estimating drop-out probabilities presented by Tvedebrink et al. [7] and the concerns, that have been raised. The criticism of the model has demonstrated that the model is not perfect. However, the model is very useful for advanced forensic genetic work, where allelic drop-out is occurring. With this discussion, we hope to improve the drop-out model, so that it can be used for practical forensic genetics and stimulate further discussions. We discuss how to estimate drop-out probabilities when using a varying number of PCR cycles and other experimental conditions.
AB - We discuss the model for estimating drop-out probabilities presented by Tvedebrink et al. [7] and the concerns, that have been raised. The criticism of the model has demonstrated that the model is not perfect. However, the model is very useful for advanced forensic genetic work, where allelic drop-out is occurring. With this discussion, we hope to improve the drop-out model, so that it can be used for practical forensic genetics and stimulate further discussions. We discuss how to estimate drop-out probabilities when using a varying number of PCR cycles and other experimental conditions.
UR - http://www.scopus.com/inward/record.url?scp=84857040596&partnerID=8YFLogxK
U2 - 10.1016/j.fsigen.2011.06.004
DO - 10.1016/j.fsigen.2011.06.004
M3 - Journal article
SN - 1872-4973
VL - 6
SP - 263
EP - 267
JO - Forensic Science International: Genetics
JF - Forensic Science International: Genetics
IS - 2
ER -