Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Caren E Smith; Jack L Follis; Hassan S Dashti; Toshiko Tanaka; Mariaelisa Graff; Amanda M Fretts; Tuomas O Kilpeläinen; Mary K Wojczynski; Kris Richardson; Mike A Nalls; Christina-Alexandra Schulz; Yongmei Liu; Alexis C Frazier-Wood; Esther van Eekelen; Carol Wang; Paul S de Vries; Vera Mikkilä; Rebecca Rohde; Bruce M Psaty; Torben Hansen; Mary F Feitosa; Chao-Qiang Lai; Denise K Houston; Luigi Ferruci; Ulrika Ericson; Zhe Wang; Renée de Mutsert; Wendy H Oddy; Ester A L de Jonge; Ilkka Seppälä; Anne E Justice; Rozenn N Lemaitre; Thorkild I A Sørensen; Michael A Province; Laurence D Parnell; Melissa E Garcia; Stefania Bandinelli; Marju Orho-Melander; Stephen S Rich; Frits R Rosendaal; Craig E Pennell; Jessica C Kiefte-de Jong; Mika Kähönen; Kristin L Young; Oluf Pedersen; Stella Aslibekyan; Jerome I Rotter; Dennis O Mook-Kanamori; M Carola Zillikens; Olli T Raitakari; Kari E North; Kim Overvad; Donna K Arnett; Albert Hofman; Terho Lehtimäki; Anne Tjønneland; André G Uitterlinden; Fernando Rivadeneira; Oscar H Franco; J Bruce German; David S Siscovick; L Adrienne Cupples; José M Ordovás

doi:10.1002/mnfr.201700347

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Caren E Smith, Jack L Follis, Hassan S Dashti, Toshiko Tanaka, Mariaelisa Graff, Amanda M Fretts, Tuomas O Kilpeläinen, Mary K Wojczynski, Kris Richardson, Mike A Nalls, Christina-Alexandra Schulz, Yongmei Liu, Alexis C Frazier-Wood, Esther van Eekelen, Carol Wang, Paul S de Vries, Vera Mikkilä, Rebecca Rohde, Bruce M Psaty, Torben HansenMary F Feitosa, Chao-Qiang Lai, Denise K Houston, Luigi Ferruci, Ulrika Ericson, Zhe Wang, Renée de Mutsert, Wendy H Oddy, Ester A L de Jonge, Ilkka Seppälä, Anne E Justice, Rozenn N Lemaitre, Thorkild I A Sørensen, Michael A Province, Laurence D Parnell, Melissa E Garcia, Stefania Bandinelli, Marju Orho-Melander, Stephen S Rich, Frits R Rosendaal, Craig E Pennell, Jessica C Kiefte-de Jong, Mika Kähönen, Kristin L Young, Oluf Pedersen, Stella Aslibekyan, Jerome I Rotter, Dennis O Mook-Kanamori, M Carola Zillikens, Olli T Raitakari, Kari E North, Kim Overvad, Donna K Arnett, Albert Hofman, Terho Lehtimäki, Anne Tjønneland, André G Uitterlinden, Fernando Rivadeneira, Oscar H Franco, J Bruce German, David S Siscovick, L Adrienne Cupples, José M Ordovás

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Abstract

Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10 ⁻⁷⁾, and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10 ⁻⁸⁾ such that each serving of low-fat dairy was associated with 0.225 kg m ⁻² lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

Original language	English
Article number	1700347
Journal	Molecular Nutrition & Food Research
Volume	62
Issue number	3
Number of pages	12
ISSN	1613-4125
DOIs	https://doi.org/10.1002/mnfr.201700347
Publication status	Published - 1 Feb 2018

Bibliographical note

Keywords

Journal Article
genome-wide interaction study
dairy intake
body mass index
meta-analysis
CHARGE consortium
Body Mass Index
European Continental Ancestry Group/genetics
Genome-Wide Association Study
Cross-Sectional Studies
Gene Frequency
Humans
Middle Aged
Genotype
Male
Myosin-Light-Chain Phosphatase/genetics
Adult
Female
Aged
Polymorphism, Single Nucleotide
Actins/genetics
Cohort Studies
Dairy Products

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803424/

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Smith, C. E., Follis, J. L., Dashti, H. S., Tanaka, T., Graff, M., Fretts, A. M., Kilpeläinen, T. O., Wojczynski, M. K., Richardson, K., Nalls, M. A., Schulz, C-A., Liu, Y., Frazier-Wood, A. C., van Eekelen, E., Wang, C., de Vries, P. S., Mikkilä, V., Rohde, R., Psaty, B. M., ... Ordovás, J. M. (2018). Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Molecular Nutrition & Food Research, 62(3), Article 1700347. https://doi.org/10.1002/mnfr.201700347

@article{275d06b244c64394b9b215719398cb09,

title = "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent",

abstract = "Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10 −7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3{\textquoteright} of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10 −8) such that each serving of low-fat dairy was associated with 0.225 kg m −2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight. ",

keywords = "Journal Article, genome-wide interaction study, dairy intake, body mass index, meta-analysis, CHARGE consortium, Body Mass Index, European Continental Ancestry Group/genetics, Genome-Wide Association Study, Cross-Sectional Studies, Gene Frequency, Humans, Middle Aged, Genotype, Male, Myosin-Light-Chain Phosphatase/genetics, Adult, Female, Aged, Polymorphism, Single Nucleotide, Actins/genetics, Cohort Studies, Dairy Products",

author = "Smith, {Caren E} and Follis, {Jack L} and Dashti, {Hassan S} and Toshiko Tanaka and Mariaelisa Graff and Fretts, {Amanda M} and Kilpel{\"a}inen, {Tuomas O} and Wojczynski, {Mary K} and Kris Richardson and Nalls, {Mike A} and Christina-Alexandra Schulz and Yongmei Liu and Frazier-Wood, {Alexis C} and {van Eekelen}, Esther and Carol Wang and {de Vries}, {Paul S} and Vera Mikkil{\"a} and Rebecca Rohde and Psaty, {Bruce M} and Torben Hansen and Feitosa, {Mary F} and Chao-Qiang Lai and Houston, {Denise K} and Luigi Ferruci and Ulrika Ericson and Zhe Wang and {de Mutsert}, Ren{\'e}e and Oddy, {Wendy H} and {de Jonge}, {Ester A L} and Ilkka Sepp{\"a}l{\"a} and Justice, {Anne E} and Lemaitre, {Rozenn N} and S{\o}rensen, {Thorkild I A} and Province, {Michael A} and Parnell, {Laurence D} and Garcia, {Melissa E} and Stefania Bandinelli and Marju Orho-Melander and Rich, {Stephen S} and Rosendaal, {Frits R} and Pennell, {Craig E} and {Kiefte-de Jong}, {Jessica C} and Mika K{\"a}h{\"o}nen and Young, {Kristin L} and Oluf Pedersen and Stella Aslibekyan and Rotter, {Jerome I} and Mook-Kanamori, {Dennis O} and Zillikens, {M Carola} and Raitakari, {Olli T} and North, {Kari E} and Kim Overvad and Arnett, {Donna K} and Albert Hofman and Terho Lehtim{\"a}ki and Anne Tj{\o}nneland and Uitterlinden, {Andr{\'e} G} and Fernando Rivadeneira and Franco, {Oscar H} and German, {J Bruce} and Siscovick, {David S} and Cupples, {L Adrienne} and Ordov{\'a}s, {Jos{\'e} M}",

note = "{\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2018",

month = feb,

day = "1",

doi = "10.1002/mnfr.201700347",

language = "English",

volume = "62",

journal = "Molecular Nutrition & Food Research",

issn = "1613-4125",

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Smith, CE, Follis, JL, Dashti, HS, Tanaka, T, Graff, M, Fretts, AM, Kilpeläinen, TO, Wojczynski, MK, Richardson, K, Nalls, MA, Schulz, C-A, Liu, Y, Frazier-Wood, AC, van Eekelen, E, Wang, C, de Vries, PS, Mikkilä, V, Rohde, R, Psaty, BM, Hansen, T, Feitosa, MF, Lai, C-Q, Houston, DK, Ferruci, L, Ericson, U, Wang, Z, de Mutsert, R, Oddy, WH, de Jonge, EAL, Seppälä, I, Justice, AE, Lemaitre, RN, Sørensen, TIA, Province, MA, Parnell, LD, Garcia, ME, Bandinelli, S, Orho-Melander, M, Rich, SS, Rosendaal, FR, Pennell, CE, Kiefte-de Jong, JC, Kähönen, M, Young, KL, Pedersen, O, Aslibekyan, S, Rotter, JI, Mook-Kanamori, DO, Zillikens, MC, Raitakari, OT, North, KE, Overvad, K, Arnett, DK, Hofman, A, Lehtimäki, T, Tjønneland, A, Uitterlinden, AG, Rivadeneira, F, Franco, OH, German, JB, Siscovick, DS, Cupples, LA & Ordovás, JM 2018, 'Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent', Molecular Nutrition & Food Research, vol. 62, no. 3, 1700347. https://doi.org/10.1002/mnfr.201700347

TY - JOUR

T1 - Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

AU - Smith, Caren E

AU - Follis, Jack L

AU - Dashti, Hassan S

AU - Tanaka, Toshiko

AU - Graff, Mariaelisa

AU - Fretts, Amanda M

AU - Kilpeläinen, Tuomas O

AU - Wojczynski, Mary K

AU - Richardson, Kris

AU - Nalls, Mike A

AU - Schulz, Christina-Alexandra

AU - Liu, Yongmei

AU - Frazier-Wood, Alexis C

AU - van Eekelen, Esther

AU - Wang, Carol

AU - de Vries, Paul S

AU - Mikkilä, Vera

AU - Rohde, Rebecca

AU - Psaty, Bruce M

AU - Hansen, Torben

AU - Feitosa, Mary F

AU - Lai, Chao-Qiang

AU - Houston, Denise K

AU - Ferruci, Luigi

AU - Ericson, Ulrika

AU - Wang, Zhe

AU - de Mutsert, Renée

AU - Oddy, Wendy H

AU - de Jonge, Ester A L

AU - Seppälä, Ilkka

AU - Justice, Anne E

AU - Lemaitre, Rozenn N

AU - Sørensen, Thorkild I A

AU - Province, Michael A

AU - Parnell, Laurence D

AU - Garcia, Melissa E

AU - Bandinelli, Stefania

AU - Orho-Melander, Marju

AU - Rich, Stephen S

AU - Rosendaal, Frits R

AU - Pennell, Craig E

AU - Kiefte-de Jong, Jessica C

AU - Kähönen, Mika

AU - Young, Kristin L

AU - Pedersen, Oluf

AU - Aslibekyan, Stella

AU - Rotter, Jerome I

AU - Mook-Kanamori, Dennis O

AU - Zillikens, M Carola

AU - Raitakari, Olli T

AU - North, Kari E

AU - Overvad, Kim

AU - Arnett, Donna K

AU - Hofman, Albert

AU - Lehtimäki, Terho

AU - Tjønneland, Anne

AU - Uitterlinden, André G

AU - Rivadeneira, Fernando

AU - Franco, Oscar H

AU - German, J Bruce

AU - Siscovick, David S

AU - Cupples, L Adrienne

AU - Ordovás, José M

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10 −7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10 −8) such that each serving of low-fat dairy was associated with 0.225 kg m −2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

AB - Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10 −7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10 −8) such that each serving of low-fat dairy was associated with 0.225 kg m −2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

KW - Journal Article

KW - genome-wide interaction study

KW - dairy intake

KW - body mass index

KW - meta-analysis

KW - CHARGE consortium

KW - Body Mass Index

KW - European Continental Ancestry Group/genetics

KW - Genome-Wide Association Study

KW - Cross-Sectional Studies

KW - Gene Frequency

KW - Humans

KW - Middle Aged

KW - Genotype

KW - Male

KW - Myosin-Light-Chain Phosphatase/genetics

KW - Adult

KW - Female

KW - Aged

KW - Polymorphism, Single Nucleotide

KW - Actins/genetics

KW - Cohort Studies

KW - Dairy Products

UR - http://www.scopus.com/inward/record.url?scp=85041378879&partnerID=8YFLogxK

U2 - 10.1002/mnfr.201700347

DO - 10.1002/mnfr.201700347

M3 - Journal article

C2 - 28941034

SN - 1613-4125

VL - 62

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 3

M1 - 1700347

ER -

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Abstract

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