Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition

Stine L Andersen; Susanne Backman Nøhr; Chun S Wu; Jørn Olsen; Klaus M Pedersen; Peter Laurberg

doi:10.1530/EJE-12-0759

Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition

Stine L Andersen, Susanne Backman Nøhr, Chun S Wu, Jørn Olsen, Klaus M Pedersen, Peter Laurberg

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Abstract

Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate from maternal smoking, but compensatory autoregulation of iodide transport differs between organs. The extent of autoregulation of placental iodide transport remains to be clarified.

Original language	English
Journal	European Journal of Endocrinology
Volume	168
Issue number	5
Pages (from-to)	723-31
Number of pages	9
ISSN	0804-4643
DOIs	https://doi.org/10.1530/EJE-12-0759
Publication status	Published - 2013

Keywords

Adult
Cross-Sectional Studies
Delivery, Obstetric
Denmark
Female
Fetal Blood
Homeostasis
Humans
Infant, Newborn
Iodine
Male
Maternal-Fetal Exchange
Pregnancy
Smoking
Thyroglobulin

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@article{2b8428fd22a34a938e60782dd2823446,

title = "Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition",

abstract = "Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate from maternal smoking, but compensatory autoregulation of iodide transport differs between organs. The extent of autoregulation of placental iodide transport remains to be clarified.",

keywords = "Adult, Cross-Sectional Studies, Delivery, Obstetric, Denmark, Female, Fetal Blood, Homeostasis, Humans, Infant, Newborn, Iodine, Male, Maternal-Fetal Exchange, Pregnancy, Smoking, Thyroglobulin",

author = "Andersen, {Stine L} and {Backman N{\o}hr}, Susanne and Wu, {Chun S} and J{\o}rn Olsen and Pedersen, {Klaus M} and Peter Laurberg",

year = "2013",

doi = "10.1530/EJE-12-0759",

language = "English",

volume = "168",

pages = "723--31",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "5",

}

Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition. / Andersen, Stine L ; Backman Nøhr, Susanne; Wu, Chun S et al.
In: European Journal of Endocrinology, Vol. 168, No. 5, 2013, p. 723-31.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition

AU - Andersen, Stine L

AU - Backman Nøhr, Susanne

AU - Wu, Chun S

AU - Olsen, Jørn

AU - Pedersen, Klaus M

AU - Laurberg, Peter

PY - 2013

Y1 - 2013

N2 - Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate from maternal smoking, but compensatory autoregulation of iodide transport differs between organs. The extent of autoregulation of placental iodide transport remains to be clarified.

AB - Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate from maternal smoking, but compensatory autoregulation of iodide transport differs between organs. The extent of autoregulation of placental iodide transport remains to be clarified.

KW - Adult

KW - Cross-Sectional Studies

KW - Delivery, Obstetric

KW - Denmark

KW - Female

KW - Fetal Blood

KW - Homeostasis

KW - Humans

KW - Infant, Newborn

KW - Iodine

KW - Male

KW - Maternal-Fetal Exchange

KW - Pregnancy

KW - Smoking

KW - Thyroglobulin

U2 - 10.1530/EJE-12-0759

DO - 10.1530/EJE-12-0759

M3 - Journal article

C2 - 23444413

SN - 0804-4643

VL - 168

SP - 723

EP - 731

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 5

ER -

Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition

Abstract

Keywords

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