Hepatitis B virus surface antigen and anti-hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV-infected patients

Bl Hønge; S Jespersen; C Medina; Ds Té; Zj da Silva; L Ostergaard; Al Laursen; C Wejse; H Krarup; C Erikstrup; Bissau HIV cohort study group

doi:10.1111/hiv.12158

Hepatitis B virus surface antigen and anti-hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV-infected patients

Bl Hønge, S Jespersen, C Medina, Ds Té, Zj da Silva, L Ostergaard, Al Laursen, C Wejse, H Krarup, C Erikstrup, Bissau HIV cohort study group

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Abstract

OBJECTIVES: In the case of coinfection with HIV and hepatitis B virus (HBV) and/or hepatitis C virus (HCV), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver-related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface antigen (HBsAg) and anti-HCV among HIV-infected patients in Guinea-Bissau.

METHODS: Blood samples from HIV-infected patients in Guinea-Bissau were stored after testing for HBsAg and anti-HCV with rapid tests. Samples were subsequently re-tested for HBsAg and anti-HCV in Denmark.

RESULTS: Two rapid tests were used in Guinea-Bissau: HBsAg Strip Ref 2034 (VEDA.LAB, Alençon, France; sensitivity 62.3%; specificity 99.2%) and HEPA-SCAN (Bhat Bio-Tech, Bangalore, India; sensitivity 57.1%; specificity 99.7%). In the two tests the ability to obtain the correct outcome depended on the antigen and antibody concentrations, respectively. Sex, age, CD4 cell count and antiretroviral therapy status did not differ between false negative and true positive samples in either of the tests. The study is limited by a low number of anti-HCV positive samples.

CONCLUSIONS: New diagnostic rapid tests should always be evaluated in the setting in which they will be used before implementation.

Original language	English
Journal	HIV Medicine
Volume	15
Issue number	9
Pages (from-to)	571-576
Number of pages	6
ISSN	1464-2662
DOIs	https://doi.org/10.1111/hiv.12158
Publication status	Published - 9 Apr 2014

Access to Document

10.1111/hiv.12158

AUB Link

Search for the material in Aalborg University Library's search engine

Cite this

@article{53b61f11c00641f4b495c7d7ef73b34e,

title = "Hepatitis B virus surface antigen and anti-hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV-infected patients",

abstract = "OBJECTIVES: In the case of coinfection with HIV and hepatitis B virus (HBV) and/or hepatitis C virus (HCV), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver-related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface antigen (HBsAg) and anti-HCV among HIV-infected patients in Guinea-Bissau.METHODS: Blood samples from HIV-infected patients in Guinea-Bissau were stored after testing for HBsAg and anti-HCV with rapid tests. Samples were subsequently re-tested for HBsAg and anti-HCV in Denmark.RESULTS: Two rapid tests were used in Guinea-Bissau: HBsAg Strip Ref 2034 (VEDA.LAB, Alen{\c c}on, France; sensitivity 62.3%; specificity 99.2%) and HEPA-SCAN (Bhat Bio-Tech, Bangalore, India; sensitivity 57.1%; specificity 99.7%). In the two tests the ability to obtain the correct outcome depended on the antigen and antibody concentrations, respectively. Sex, age, CD4 cell count and antiretroviral therapy status did not differ between false negative and true positive samples in either of the tests. The study is limited by a low number of anti-HCV positive samples.CONCLUSIONS: New diagnostic rapid tests should always be evaluated in the setting in which they will be used before implementation.",

author = "Bl H{\o}nge and S Jespersen and C Medina and Ds T{\'e} and {da Silva}, Zj and L Ostergaard and Al Laursen and C Wejse and H Krarup and C Erikstrup and {Bissau HIV cohort study group}",

note = "{\textcopyright} 2014 British HIV Association.",

year = "2014",

month = apr,

day = "9",

doi = "10.1111/hiv.12158",

language = "English",

volume = "15",

pages = "571--576",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "Wiley-Blackwell",

number = "9",

}

Hønge, B, Jespersen, S, Medina, C, Té, D, da Silva, Z, Ostergaard, L, Laursen, A, Wejse, C, Krarup, H, Erikstrup, C & Bissau HIV cohort study group 2014, 'Hepatitis B virus surface antigen and anti-hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV-infected patients', HIV Medicine, vol. 15, no. 9, pp. 571-576. https://doi.org/10.1111/hiv.12158

TY - JOUR

T1 - Hepatitis B virus surface antigen and anti-hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV-infected patients

AU - Hønge, Bl

AU - Jespersen, S

AU - Medina, C

AU - Té, Ds

AU - da Silva, Zj

AU - Ostergaard, L

AU - Laursen, Al

AU - Wejse, C

AU - Krarup, H

AU - Erikstrup, C

AU - Bissau HIV cohort study group

PY - 2014/4/9

Y1 - 2014/4/9

N2 - OBJECTIVES: In the case of coinfection with HIV and hepatitis B virus (HBV) and/or hepatitis C virus (HCV), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver-related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface antigen (HBsAg) and anti-HCV among HIV-infected patients in Guinea-Bissau.METHODS: Blood samples from HIV-infected patients in Guinea-Bissau were stored after testing for HBsAg and anti-HCV with rapid tests. Samples were subsequently re-tested for HBsAg and anti-HCV in Denmark.RESULTS: Two rapid tests were used in Guinea-Bissau: HBsAg Strip Ref 2034 (VEDA.LAB, Alençon, France; sensitivity 62.3%; specificity 99.2%) and HEPA-SCAN (Bhat Bio-Tech, Bangalore, India; sensitivity 57.1%; specificity 99.7%). In the two tests the ability to obtain the correct outcome depended on the antigen and antibody concentrations, respectively. Sex, age, CD4 cell count and antiretroviral therapy status did not differ between false negative and true positive samples in either of the tests. The study is limited by a low number of anti-HCV positive samples.CONCLUSIONS: New diagnostic rapid tests should always be evaluated in the setting in which they will be used before implementation.

AB - OBJECTIVES: In the case of coinfection with HIV and hepatitis B virus (HBV) and/or hepatitis C virus (HCV), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver-related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface antigen (HBsAg) and anti-HCV among HIV-infected patients in Guinea-Bissau.METHODS: Blood samples from HIV-infected patients in Guinea-Bissau were stored after testing for HBsAg and anti-HCV with rapid tests. Samples were subsequently re-tested for HBsAg and anti-HCV in Denmark.RESULTS: Two rapid tests were used in Guinea-Bissau: HBsAg Strip Ref 2034 (VEDA.LAB, Alençon, France; sensitivity 62.3%; specificity 99.2%) and HEPA-SCAN (Bhat Bio-Tech, Bangalore, India; sensitivity 57.1%; specificity 99.7%). In the two tests the ability to obtain the correct outcome depended on the antigen and antibody concentrations, respectively. Sex, age, CD4 cell count and antiretroviral therapy status did not differ between false negative and true positive samples in either of the tests. The study is limited by a low number of anti-HCV positive samples.CONCLUSIONS: New diagnostic rapid tests should always be evaluated in the setting in which they will be used before implementation.

U2 - 10.1111/hiv.12158

DO - 10.1111/hiv.12158

M3 - Journal article

C2 - 24717010

SN - 1464-2662

VL - 15

SP - 571

EP - 576

JO - HIV Medicine

JF - HIV Medicine

IS - 9

ER -

Hepatitis B virus surface antigen and anti-hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV-infected patients

Abstract

Access to Document

AUB Link

Fingerprint

Cite this