Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity

R E Burgell; D Lelic; E V Carrington; P J Lunniss; S S Olesen; S Surguy; A M Drewes; S M Scott

doi:10.1111/nmo.12047

Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity

R E Burgell, D Lelic, E V Carrington, P J Lunniss, S S Olesen, S Surguy, A M Drewes, S M Scott

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Abstract

Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined.

Original language	English
Journal	Neurogastroenterology and Motility Online
Volume	25
Issue number	3
Pages (from-to)	260-7, e167-8
ISSN	1365-2982
DOIs	https://doi.org/10.1111/nmo.12047
Publication status	Published - Mar 2013

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title = "Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity",

abstract = "Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined.",

author = "Burgell, {R E} and D Lelic and Carrington, {E V} and Lunniss, {P J} and Olesen, {S S} and S Surguy and Drewes, {A M} and Scott, {S M}",

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AU - Burgell, R E

AU - Lelic, D

AU - Carrington, E V

AU - Lunniss, P J

AU - Olesen, S S

AU - Surguy, S

AU - Drewes, A M

AU - Scott, S M

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N2 - Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined.

AB - Blunted rectal sensation (rectal hyposensitivity: RH) is present in almost one-quarter of patients with chronic constipation. The mechanisms of its development are not fully understood, but in a proportion, afferent dysfunction is likely. To determine if, in patients with RH, alteration of rectal sensory pathways exists, rectal evoked potentials (EPs) and inverse modeling of cortical dipoles were examined.

U2 - 10.1111/nmo.12047

DO - 10.1111/nmo.12047

M3 - Journal article

C2 - 23240734

SN - 1365-2982

VL - 25

SP - 260-7, e167-8

JO - Neurogastroenterology and Motility Online

JF - Neurogastroenterology and Motility Online

IS - 3

ER -

Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity

Abstract

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