Distensibility of the anal canal in patients with systemic sclerosis: A study with the functional lumen imaging probe

L Fynne; F Luft; H Gregersen; S Buntzen; L Lundby; Flemming Holbæk  Lundager; S Laurberg; K. Krogh

doi:10.1111/codi.12063

Distensibility of the anal canal in patients with systemic sclerosis: A study with the functional lumen imaging probe

L Fynne, F Luft, H Gregersen, S Buntzen, L Lundby, Flemming Holbæk Lundager, S Laurberg, K. Krogh

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Systemic sclerosis (SSc) is a generalized connective tissue disease that affects smooth muscle cells. Patients with SSc often have faecal incontinence caused by fibrotic degeneration of the internal anal sphincter (IAS). The functional lumen imaging probe (FLIP) is a novel method that allows the segmental biomechanical properties of the anal canal to be dynamically evaluated. The aim of the present study was to compare the segmental biomechanical properties of the anal canal in incontinent SSc patients and healthy controls. We hypothesized that the FLIP would reveal weaknesses of the IAS in the SSc patients.

Original language	English
Journal	Colorectal Disease
Volume	15
Issue number	1
Pages (from-to)	e40-e47
ISSN	1462-8910
DOIs	https://doi.org/10.1111/codi.12063
Publication status	Published - 2013

Keywords

Adult
Aged
Aged, 80 and over
Anal Canal
Biomechanics
Case-Control Studies
Endosonography
Fecal Incontinence
Female
Humans
Linear Models
Male
Manometry
Middle Aged
Muscle, Smooth
Scleroderma, Systemic

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title = "Distensibility of the anal canal in patients with systemic sclerosis: A study with the functional lumen imaging probe",

abstract = "Systemic sclerosis (SSc) is a generalized connective tissue disease that affects smooth muscle cells. Patients with SSc often have faecal incontinence caused by fibrotic degeneration of the internal anal sphincter (IAS). The functional lumen imaging probe (FLIP) is a novel method that allows the segmental biomechanical properties of the anal canal to be dynamically evaluated. The aim of the present study was to compare the segmental biomechanical properties of the anal canal in incontinent SSc patients and healthy controls. We hypothesized that the FLIP would reveal weaknesses of the IAS in the SSc patients.",

keywords = "Adult, Aged, Aged, 80 and over, Anal Canal, Biomechanics, Case-Control Studies, Endosonography, Fecal Incontinence, Female, Humans, Linear Models, Male, Manometry, Middle Aged, Muscle, Smooth, Scleroderma, Systemic",

author = "L Fynne and F Luft and H Gregersen and S Buntzen and L Lundby and Lundager, {Flemming Holb{\ae}k} and S Laurberg and K. Krogh",

note = "{\textcopyright} 2012 The Authors Colorectal Disease {\textcopyright} 2012 The Association of Coloproctology of Great Britain and Ireland.",

year = "2013",

doi = "10.1111/codi.12063",

language = "English",

volume = "15",

pages = "e40--e47",

journal = "Colorectal Disease",

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TY - JOUR

T1 - Distensibility of the anal canal in patients with systemic sclerosis

T2 - A study with the functional lumen imaging probe

AU - Fynne, L

AU - Luft, F

AU - Gregersen, H

AU - Buntzen, S

AU - Lundby, L

AU - Lundager, Flemming Holbæk

AU - Laurberg, S

AU - Krogh, K.

PY - 2013

Y1 - 2013

N2 - Systemic sclerosis (SSc) is a generalized connective tissue disease that affects smooth muscle cells. Patients with SSc often have faecal incontinence caused by fibrotic degeneration of the internal anal sphincter (IAS). The functional lumen imaging probe (FLIP) is a novel method that allows the segmental biomechanical properties of the anal canal to be dynamically evaluated. The aim of the present study was to compare the segmental biomechanical properties of the anal canal in incontinent SSc patients and healthy controls. We hypothesized that the FLIP would reveal weaknesses of the IAS in the SSc patients.

AB - Systemic sclerosis (SSc) is a generalized connective tissue disease that affects smooth muscle cells. Patients with SSc often have faecal incontinence caused by fibrotic degeneration of the internal anal sphincter (IAS). The functional lumen imaging probe (FLIP) is a novel method that allows the segmental biomechanical properties of the anal canal to be dynamically evaluated. The aim of the present study was to compare the segmental biomechanical properties of the anal canal in incontinent SSc patients and healthy controls. We hypothesized that the FLIP would reveal weaknesses of the IAS in the SSc patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anal Canal

KW - Biomechanics

KW - Case-Control Studies

KW - Endosonography

KW - Fecal Incontinence

KW - Female

KW - Humans

KW - Linear Models

KW - Male

KW - Manometry

KW - Middle Aged

KW - Muscle, Smooth

KW - Scleroderma, Systemic

U2 - 10.1111/codi.12063

DO - 10.1111/codi.12063

M3 - Journal article

C2 - 23067109

SN - 1462-8910

VL - 15

SP - e40-e47

JO - Colorectal Disease

JF - Colorectal Disease

IS - 1

ER -

Distensibility of the anal canal in patients with systemic sclerosis: A study with the functional lumen imaging probe

Abstract

Keywords

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