The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania

Andreas V Jensen, Lotte Jensen, Daniel Faurholt-Jepsen, Martine G Aabye, George Praygod, Jeremiah Kidola, Maria Faurholt-Jepsen, John Changalucha, Nyagosya Range, Henrik Krarup, Henrik Friis, Aase B Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

15 Citations (Scopus)

Abstract

One third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis (LTBI). Surveys of LTBI are rarely performed in resource poor TB high endemic countries like Tanzania although low-income countries harbor the largest burden of the worlds LTBI. The primary objective was to estimate the prevalence of LTBI in household contacts of pulmonary TB cases and a group of apparently healthy neighborhood controls in an urban setting of such a country. Secondly we assessed potential impact of LTBI on inflammation by quantitating circulating levels of an acute phase reactant: alpha-1-acid glycoprotein (AGP) in neighborhood controls.
Original languageEnglish
JournalP L o S One
Volume8
Issue number5
Pages (from-to)e64008
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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