MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans

Ming Zhang; Yunfang Joan Hou; Erdal Cavusoglu; Daniel C Lee; Rudi Steffensen; Liming Yang; Daniel Bashari; Jose Villamil; Motaz Moussa; George Fernaine; Jens Christian Jensenius; Jonathan D Marmur; Wilson Ko; Ketan Shevde

doi:10.1016/j.ijcard.2011.11.032

MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans

Ming Zhang, Yunfang Joan Hou, Erdal Cavusoglu, Daniel C Lee, Rudi Steffensen, Liming Yang, Daniel Bashari, Jose Villamil, Motaz Moussa, George Fernaine, Jens Christian Jensenius, Jonathan D Marmur, Wilson Ko, Ketan Shevde

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Abstract

Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery.

Original language	English
Journal	International Journal of Cardiology
Volume	166
Issue number	2
Pages (from-to)	499-504
Number of pages	6
ISSN	0167-5273
DOIs	https://doi.org/10.1016/j.ijcard.2011.11.032
Publication status	Published - 20 Jun 2013

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Zhang, M., Hou, Y. J., Cavusoglu, E., Lee, D. C., Steffensen, R., Yang, L., Bashari, D., Villamil, J., Moussa, M., Fernaine, G., Jensenius, J. C., Marmur, J. D., Ko, W., & Shevde, K. (2013). MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans. International Journal of Cardiology, 166(2), 499-504. https://doi.org/10.1016/j.ijcard.2011.11.032

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abstract = "Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery.",

author = "Ming Zhang and Hou, {Yunfang Joan} and Erdal Cavusoglu and Lee, {Daniel C} and Rudi Steffensen and Liming Yang and Daniel Bashari and Jose Villamil and Motaz Moussa and George Fernaine and Jensenius, {Jens Christian} and Marmur, {Jonathan D} and Wilson Ko and Ketan Shevde",

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AU - Zhang, Ming

AU - Hou, Yunfang Joan

AU - Cavusoglu, Erdal

AU - Lee, Daniel C

AU - Steffensen, Rudi

AU - Yang, Liming

AU - Bashari, Daniel

AU - Villamil, Jose

AU - Moussa, Motaz

AU - Fernaine, George

AU - Jensenius, Jens Christian

AU - Marmur, Jonathan D

AU - Ko, Wilson

AU - Shevde, Ketan

PY - 2013/6/20

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N2 - Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery.

AB - Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery.

U2 - 10.1016/j.ijcard.2011.11.032

DO - 10.1016/j.ijcard.2011.11.032

M3 - Journal article

C2 - 22178059

SN - 0167-5273

VL - 166

SP - 499

EP - 504

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans

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