TY - JOUR
T1 - Use of psychotropic drugs following venous thromboembolism in youth
T2 - a nationwide cohort study
AU - Wind, Anette Arbjerg
AU - Gorst-Rasmussen, Anders
AU - Lip, Gregory Y H
AU - Lane, Deirdre A
AU - Rasmussen, Lars Hvilsted
AU - Sørensen, Erik Elgaard
AU - Larsen, Torben Bjerregaard
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/1/24
Y1 - 2015/1/24
N2 - INTRODUCTION: The mental health prognosis following a venous thromboembolism in youth has not been investigated comprehensively. Using psychotropic drug purchase as a proxy for mental health status, we investigated this issue in a large cohort of young incident venous thromboembolism patients.METHODS: Using Danish nationwide administrative registries from the period 1997-2010, we identified 4,132 patients aged 13-33 years with a first-time venous thromboembolism diagnosis and no history of psychotropic drug usage. We sampled comparison cohort of random general population controls, matched individually in a 1:5 ratio based on sex and birth year. Participants were followed in prescription purchase registries for their first psychotropic drug purchase.RESULTS: Among young venous thromboembolism case cases, the 1-year risk of psychotropic drug purchase was 7.1% (95% confidence interval [CI] 6.3, 7.9) and the 5-year risk 22.1% (95% CI 20.7, 23.5). This was substantially higher than among population controls, with 1- and 5-year risk differences relative to the controls of 4.7% (95% CI 3.9, 5.5), and 10.8% (95% CI 9.4, 12.3), respectively. Adjustment for the effects of recent pregnancy or somatic provocations attenuated risk differences to 4.1% (95% CI 3.5, 5.1) after 1year and 9.6% (95% CI 8.3, 11.2) after 5years.CONCLUSIONS: A venous thromboembolism diagnosis in youth is associated with a poorer mental health prognosis: one in five patients are prescribed psychotropic medication within the first 5year after diagnosis.
AB - INTRODUCTION: The mental health prognosis following a venous thromboembolism in youth has not been investigated comprehensively. Using psychotropic drug purchase as a proxy for mental health status, we investigated this issue in a large cohort of young incident venous thromboembolism patients.METHODS: Using Danish nationwide administrative registries from the period 1997-2010, we identified 4,132 patients aged 13-33 years with a first-time venous thromboembolism diagnosis and no history of psychotropic drug usage. We sampled comparison cohort of random general population controls, matched individually in a 1:5 ratio based on sex and birth year. Participants were followed in prescription purchase registries for their first psychotropic drug purchase.RESULTS: Among young venous thromboembolism case cases, the 1-year risk of psychotropic drug purchase was 7.1% (95% confidence interval [CI] 6.3, 7.9) and the 5-year risk 22.1% (95% CI 20.7, 23.5). This was substantially higher than among population controls, with 1- and 5-year risk differences relative to the controls of 4.7% (95% CI 3.9, 5.5), and 10.8% (95% CI 9.4, 12.3), respectively. Adjustment for the effects of recent pregnancy or somatic provocations attenuated risk differences to 4.1% (95% CI 3.5, 5.1) after 1year and 9.6% (95% CI 8.3, 11.2) after 5years.CONCLUSIONS: A venous thromboembolism diagnosis in youth is associated with a poorer mental health prognosis: one in five patients are prescribed psychotropic medication within the first 5year after diagnosis.
U2 - 10.1016/j.thromres.2015.01.024
DO - 10.1016/j.thromres.2015.01.024
M3 - Journal article
C2 - 25661687
SN - 0049-3848
VL - 135
SP - 643
EP - 647
JO - Thrombosis Research
JF - Thrombosis Research
IS - 4
ER -