TY - JOUR
T1 - A method for estimation of plasma albumin concentration from the buffering properties of whole blood
AU - Rees, Stephen Edward
AU - Diemer, Tue
AU - Kristensen, Søren Risom
PY - 2012
Y1 - 2012
N2 - PURPOSE: Hypoalbuminemia is strongly associated with poor clinical outcome. Albumin is usually measured at the central laboratory rather than point of care, but in principle, information exists in the buffering properties of whole blood to estimate plasma albumin concentration from point of care measurements of acid-base and oxygenation status. This article presents and evaluates a new method for doing so. MATERIALS AND METHODS: The mathematical method for estimating plasma albumin concentration is described. To evaluate the method at numerous albumin concentrations, blood from 19 healthy subjects was diluted at 3 different levels giving 57 data sets. Calculated and measured plasma albumin concentrations were compared using correlation coefficient (r(2)), regression line, and Bland-Altman bias and limits of agreement. RESULTS: Albumin levels covered the clinically interesting range from 8.8 to 53.3 g/L. Calculated and measured plasma albumin concentrations compared well with r(2) = 0.9, a regression line of albumin-calculated = 1.05 × albumin-measured - 2.25, a small average bias between measured and calculated values of 0.7 g/L, and Bland-Altman limits of agreement of 10 g/L. CONCLUSIONS: This new method may be a valuable tool in screening and monitoring plasma albumin concentration in acutely ill patients, from measurements taken at the point of care.
AB - PURPOSE: Hypoalbuminemia is strongly associated with poor clinical outcome. Albumin is usually measured at the central laboratory rather than point of care, but in principle, information exists in the buffering properties of whole blood to estimate plasma albumin concentration from point of care measurements of acid-base and oxygenation status. This article presents and evaluates a new method for doing so. MATERIALS AND METHODS: The mathematical method for estimating plasma albumin concentration is described. To evaluate the method at numerous albumin concentrations, blood from 19 healthy subjects was diluted at 3 different levels giving 57 data sets. Calculated and measured plasma albumin concentrations were compared using correlation coefficient (r(2)), regression line, and Bland-Altman bias and limits of agreement. RESULTS: Albumin levels covered the clinically interesting range from 8.8 to 53.3 g/L. Calculated and measured plasma albumin concentrations compared well with r(2) = 0.9, a regression line of albumin-calculated = 1.05 × albumin-measured - 2.25, a small average bias between measured and calculated values of 0.7 g/L, and Bland-Altman limits of agreement of 10 g/L. CONCLUSIONS: This new method may be a valuable tool in screening and monitoring plasma albumin concentration in acutely ill patients, from measurements taken at the point of care.
UR - http://www.scopus.com/inward/record.url?scp=84867330406&partnerID=8YFLogxK
U2 - 10.1016/j.jcrc.2012.02.011
DO - 10.1016/j.jcrc.2012.02.011
M3 - Journal article
SN - 0883-9441
VL - 27
SP - 534.e1-534.e6
JO - Journal of Critical Care
JF - Journal of Critical Care
IS - 5
ER -