Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women

Christine Dalgård; Lene Christiansen; Ulla Vogel; Claus Dethlefsen; Anne Tjønneland; Kim Overvad

doi:10.1371/journal.pone.0070421

Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women

Christine Dalgård, Lene Christiansen, Ulla Vogel, Claus Dethlefsen, Anne Tjønneland, Kim Overvad

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome.

Original language	English
Article number	e70421
Journal	P L o S One
Volume	8
Issue number	8
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0070421
Publication status	Published - 2013

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abstract = "Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome.",

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AU - Dalgård, Christine

AU - Christiansen, Lene

AU - Vogel, Ulla

AU - Dethlefsen, Claus

AU - Tjønneland, Anne

AU - Overvad, Kim

PY - 2013

Y1 - 2013

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AB - Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome.

U2 - 10.1371/journal.pone.0070421

DO - 10.1371/journal.pone.0070421

M3 - Journal article

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ER -

Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women

Abstract

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