TY - JOUR
T1 - Prevalence of posttraumatic growth hormone deficiency is highly dependent on the diagnostic set-up - results from The Danish National study on posttraumatic hypopituitarism
AU - Klose, Marianne
AU - Stochholm, Kirstine
AU - Janukonyté, Jourgita
AU - Lehman Christensen, Louise
AU - Frystyk, Jan
AU - Andersen, Marianne
AU - Laurberg, Peter
AU - Sandahl Christiansen, Jens
AU - Feldt-Rasmussen, Ulla
PY - 2014
Y1 - 2014
N2 - ContextRecent international guidelines suggest pituitary screening in patients with moderate and severe traumatic brain injury (TBI). Predominantly isolated GH deficiency (GHD) was reported in the literature raising the question of potential methodological bias.ObjectiveTo assess the prevalence of GHD in patients admitted in 2008 with TBI, with concurrent assessment of methodological bias.DesignNationwide population based cohort studySettingTertiary referral University HospitalsParticipantsDanish patients with a head trauma diagnosis from Danish Board of Health diagnostic code registry; 439 patients and 124 healthy controls underwent dynamic assessment of GH secretion median 2.5 years after TBI.Main outcomePrevalence of GHD given use of 1) local versus guideline cut-offs, 2) insulin tolerance test (ITT), pyridostigmin-GHRH (PD-GHRH) or GHRH-arginine (GHRH-arg) test, 3) single versus repeated testing, and 4) GH-assessment by assays with different isoform specificity.ResultsThe prevalence of GHD was lower by local than guideline cut-offs (12% vs. 19% (PD-GHRH/GHRH-arg, P
AB - ContextRecent international guidelines suggest pituitary screening in patients with moderate and severe traumatic brain injury (TBI). Predominantly isolated GH deficiency (GHD) was reported in the literature raising the question of potential methodological bias.ObjectiveTo assess the prevalence of GHD in patients admitted in 2008 with TBI, with concurrent assessment of methodological bias.DesignNationwide population based cohort studySettingTertiary referral University HospitalsParticipantsDanish patients with a head trauma diagnosis from Danish Board of Health diagnostic code registry; 439 patients and 124 healthy controls underwent dynamic assessment of GH secretion median 2.5 years after TBI.Main outcomePrevalence of GHD given use of 1) local versus guideline cut-offs, 2) insulin tolerance test (ITT), pyridostigmin-GHRH (PD-GHRH) or GHRH-arginine (GHRH-arg) test, 3) single versus repeated testing, and 4) GH-assessment by assays with different isoform specificity.ResultsThe prevalence of GHD was lower by local than guideline cut-offs (12% vs. 19% (PD-GHRH/GHRH-arg, P
U2 - 10.1210/jc.2013-2397
DO - 10.1210/jc.2013-2397
M3 - Journal article
C2 - 24243629
SN - 0021-972X
VL - 99
SP - 101
EP - 110
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 1
ER -