Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study

Torben Bjerregaard Larsen; Lars Hvilsted Rasmussen; Flemming Skjøth; Karen Margrete Due; Torbjörn Callréus; Mary Rosenzweig; Gregory Y H Lip

doi:10.1016/j.jacc.2013.03.020

Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study

Torben Bjerregaard Larsen, Lars Hvilsted Rasmussen, Flemming Skjøth, Karen Margrete Due, Torbjörn Callréus, Mary Rosenzweig, Gregory Y H Lip

Research output: Contribution to journal › Journal article › Research › peer-review

389 Citations (Scopus)

Abstract

The aim of this study was to assess the efficacy and safety in an "everyday clinical practice" population of anticoagulant-naïve patients with atrial fibrillation (AF) treated with dabigatran etexilate after its post-approval availability in Denmark, compared with warfarin.

Original language	English
Journal	Journal of the American College of Cardiology
Volume	61
Issue number	22
Pages (from-to)	2264-2273
Number of pages	10
ISSN	0735-1097
DOIs	https://doi.org/10.1016/j.jacc.2013.03.020
Publication status	Published - 4 Jun 2013

Keywords

Aged
Aged, 80 and over
Anticoagulants
Antithrombins
Atrial Fibrillation
Benzimidazoles
Denmark
Dose-Response Relationship, Drug
Drug Prescriptions
Female
Follow-Up Studies
Gastrointestinal Hemorrhage
Hospitalization
Humans
Incidence
Intracranial Hemorrhages
Logistic Models
Male
Myocardial Infarction
Propensity Score
Proportional Hazards Models
Prospective Studies
Pulmonary Embolism
Pyridines
Registries
Stroke
Warfarin

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10.1016/j.jacc.2013.03.020

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title = "Efficacy and safety of dabigatran etexilate and warfarin in {"}real-world{"} patients with atrial fibrillation: a prospective nationwide cohort study",

abstract = "The aim of this study was to assess the efficacy and safety in an {"}everyday clinical practice{"} population of anticoagulant-na{\"i}ve patients with atrial fibrillation (AF) treated with dabigatran etexilate after its post-approval availability in Denmark, compared with warfarin.",

keywords = "Aged, Aged, 80 and over, Anticoagulants, Antithrombins, Atrial Fibrillation, Benzimidazoles, Denmark, Dose-Response Relationship, Drug, Drug Prescriptions, Female, Follow-Up Studies, Gastrointestinal Hemorrhage, Hospitalization, Humans, Incidence, Intracranial Hemorrhages, Logistic Models, Male, Myocardial Infarction, Propensity Score, Proportional Hazards Models, Prospective Studies, Pulmonary Embolism, Pyridines, Registries, Stroke, Warfarin",

author = "Larsen, {Torben Bjerregaard} and Rasmussen, {Lars Hvilsted} and Flemming Skj{\o}th and Due, {Karen Margrete} and Torbj{\"o}rn Callr{\'e}us and Mary Rosenzweig and Lip, {Gregory Y H}",

year = "2013",

month = jun,

day = "4",

doi = "10.1016/j.jacc.2013.03.020",

language = "English",

volume = "61",

pages = "2264--2273",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier",

number = "22",

}

Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study. / Larsen, Torben Bjerregaard ; Rasmussen, Lars Hvilsted ; Skjøth, Flemming et al.
In: Journal of the American College of Cardiology, Vol. 61, No. 22, 04.06.2013, p. 2264-2273.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation

T2 - a prospective nationwide cohort study

AU - Larsen, Torben Bjerregaard

AU - Rasmussen, Lars Hvilsted

AU - Skjøth, Flemming

AU - Due, Karen Margrete

AU - Callréus, Torbjörn

AU - Rosenzweig, Mary

AU - Lip, Gregory Y H

PY - 2013/6/4

Y1 - 2013/6/4

N2 - The aim of this study was to assess the efficacy and safety in an "everyday clinical practice" population of anticoagulant-naïve patients with atrial fibrillation (AF) treated with dabigatran etexilate after its post-approval availability in Denmark, compared with warfarin.

AB - The aim of this study was to assess the efficacy and safety in an "everyday clinical practice" population of anticoagulant-naïve patients with atrial fibrillation (AF) treated with dabigatran etexilate after its post-approval availability in Denmark, compared with warfarin.

KW - Aged

KW - Aged, 80 and over

KW - Anticoagulants

KW - Antithrombins

KW - Atrial Fibrillation

KW - Benzimidazoles

KW - Denmark

KW - Dose-Response Relationship, Drug

KW - Drug Prescriptions

KW - Female

KW - Follow-Up Studies

KW - Gastrointestinal Hemorrhage

KW - Hospitalization

KW - Humans

KW - Incidence

KW - Intracranial Hemorrhages

KW - Logistic Models

KW - Male

KW - Myocardial Infarction

KW - Propensity Score

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Pulmonary Embolism

KW - Pyridines

KW - Registries

KW - Stroke

KW - Warfarin

U2 - 10.1016/j.jacc.2013.03.020

DO - 10.1016/j.jacc.2013.03.020

M3 - Journal article

C2 - 23562920

SN - 0735-1097

VL - 61

SP - 2264

EP - 2273

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 22

ER -

Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study

Abstract

Keywords

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