Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

B Albrecht; D Brandeis; H Uebel; L Valko; H Heinrich; R Drechsler; A Heise; U C Müller; H-C Steinhausen; A Rothenberger; T Banaschewski

doi:10.1017/S003329171200270X

Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

B Albrecht, D Brandeis, H Uebel, L Valko, H Heinrich, R Drechsler, A Heise, U C Müller, H-C Steinhausen, A Rothenberger, T Banaschewski

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43).

Original language	English
Journal	Psychological Medicine
Volume	43
Issue number	9
Pages (from-to)	1997-2011
Number of pages	15
ISSN	0033-2917
DOIs	https://doi.org/10.1017/S003329171200270X
Publication status	Published - Sept 2013

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title = "Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder",

abstract = "Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43).",

author = "B Albrecht and D Brandeis and H Uebel and L Valko and H Heinrich and R Drechsler and A Heise and M{\"u}ller, {U C} and H-C Steinhausen and A Rothenberger and T Banaschewski",

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doi = "10.1017/S003329171200270X",

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T1 - Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

AU - Albrecht, B

AU - Brandeis, D

AU - Uebel, H

AU - Valko, L

AU - Heinrich, H

AU - Drechsler, R

AU - Heise, A

AU - Müller, U C

AU - Steinhausen, H-C

AU - Rothenberger, A

AU - Banaschewski, T

PY - 2013/9

Y1 - 2013/9

N2 - Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43).

AB - Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43).

U2 - 10.1017/S003329171200270X

DO - 10.1017/S003329171200270X

M3 - Journal article

C2 - 23200032

SN - 0033-2917

VL - 43

SP - 1997

EP - 2011

JO - Psychological Medicine

JF - Psychological Medicine

IS - 9

ER -

Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

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