Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort

V A Grote; R Kaaks; A Nieters; A Tjønneland; Jytte Halkjær; K Overvad; Michael René Skjelbo Nielsen; M C Boutron-Ruault; F Clavel-Chapelon; A Racine; B Teucher; S Becker; T Pischon; H Boeing; A Trichopoulou; C Cassapa; V Stratigakou; D Palli; V Krogh; R Tumino; P Vineis; S Panico; L Rodríguez; E J Duell; M-J Sánchez; M Dorronsoro; C Navarro; A B Gurrea; P D Siersema; P Hm Peeters; W Ye; M Sund; B Lindkvist; D Johansen; K-T Khaw; N Wareham; N E Allen; R C Travis; V Fedirko; M Jenab; D S Michaud; S-C Chuang; D Romaguera; H B Bueno-de-Mesquita; S Rohrmann

doi:10.1038/bjc.2012.172

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort

V A Grote, R Kaaks, A Nieters, A Tjønneland, Jytte Halkjær, K Overvad, Michael René Skjelbo Nielsen, M C Boutron-Ruault, F Clavel-Chapelon, A Racine, B Teucher, S Becker, T Pischon, H Boeing, A Trichopoulou, C Cassapa, V Stratigakou, D Palli, V Krogh, R TuminoP Vineis, S Panico, L Rodríguez, E J Duell, M-J Sánchez, M Dorronsoro, C Navarro, A B Gurrea, P D Siersema, P Hm Peeters, W Ye, M Sund, B Lindkvist, D Johansen, K-T Khaw, N Wareham, N E Allen, R C Travis, V Fedirko, M Jenab, D S Michaud, S-C Chuang, D Romaguera, H B Bueno-de-Mesquita, S Rohrmann

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Background:Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce.Methods:We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models.Results:None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI.Conclusion:Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer.

Original language	English
Journal	British Journal of Cancer
Volume	106
Pages (from-to)	1866-74
Number of pages	9
ISSN	0007-0920
DOIs	https://doi.org/10.1038/bjc.2012.172
Publication status	Published - 22 May 2012
Externally published	Yes

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Grote, V. A., Kaaks, R., Nieters, A., Tjønneland, A., Halkjær, J., Overvad, K., Nielsen, M. R. S., Boutron-Ruault, M. C., Clavel-Chapelon, F., Racine, A., Teucher, B., Becker, S., Pischon, T., Boeing, H., Trichopoulou, A., Cassapa, C., Stratigakou, V., Palli, D., Krogh, V., ... Rohrmann, S. (2012). Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. British Journal of Cancer, 106, 1866-74. https://doi.org/10.1038/bjc.2012.172

@article{6b66ad11c8b74423a9d9c62c09a7e516,

title = "Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort",

abstract = "Background:Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce.Methods:We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models.Results:None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI.Conclusion:Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer.",

author = "Grote, {V A} and R Kaaks and A Nieters and A Tj{\o}nneland and Jytte Halkj{\ae}r and K Overvad and Nielsen, {Michael Ren{\'e} Skjelbo} and Boutron-Ruault, {M C} and F Clavel-Chapelon and A Racine and B Teucher and S Becker and T Pischon and H Boeing and A Trichopoulou and C Cassapa and V Stratigakou and D Palli and V Krogh and R Tumino and P Vineis and S Panico and L Rodr{\'i}guez and Duell, {E J} and M-J S{\'a}nchez and M Dorronsoro and C Navarro and Gurrea, {A B} and Siersema, {P D} and {Hm Peeters}, P and W Ye and M Sund and B Lindkvist and D Johansen and K-T Khaw and N Wareham and Allen, {N E} and Travis, {R C} and V Fedirko and M Jenab and Michaud, {D S} and S-C Chuang and D Romaguera and Bueno-de-Mesquita, {H B} and S Rohrmann",

year = "2012",

month = may,

day = "22",

doi = "10.1038/bjc.2012.172",

language = "English",

volume = "106",

pages = "1866--74",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

}

Grote, VA, Kaaks, R, Nieters, A, Tjønneland, A, Halkjær, J, Overvad, K, Nielsen, MRS, Boutron-Ruault, MC, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodríguez, L, Duell, EJ, Sánchez, M-J, Dorronsoro, M, Navarro, C, Gurrea, AB, Siersema, PD, Hm Peeters, P, Ye, W, Sund, M, Lindkvist, B, Johansen, D, Khaw, K-T, Wareham, N, Allen, NE, Travis, RC, Fedirko, V, Jenab, M, Michaud, DS, Chuang, S-C, Romaguera, D, Bueno-de-Mesquita, HB & Rohrmann, S 2012, 'Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort', British Journal of Cancer, vol. 106, pp. 1866-74. https://doi.org/10.1038/bjc.2012.172

TY - JOUR

T1 - Inflammation marker and risk of pancreatic cancer

T2 - a nested case-control study within the EPIC cohort

AU - Grote, V A

AU - Kaaks, R

AU - Nieters, A

AU - Tjønneland, A

AU - Halkjær, Jytte

AU - Overvad, K

AU - Nielsen, Michael René Skjelbo

AU - Boutron-Ruault, M C

AU - Clavel-Chapelon, F

AU - Racine, A

AU - Teucher, B

AU - Becker, S

AU - Pischon, T

AU - Boeing, H

AU - Trichopoulou, A

AU - Cassapa, C

AU - Stratigakou, V

AU - Palli, D

AU - Krogh, V

AU - Tumino, R

AU - Vineis, P

AU - Panico, S

AU - Rodríguez, L

AU - Duell, E J

AU - Sánchez, M-J

AU - Dorronsoro, M

AU - Navarro, C

AU - Gurrea, A B

AU - Siersema, P D

AU - Hm Peeters, P

AU - Ye, W

AU - Sund, M

AU - Lindkvist, B

AU - Johansen, D

AU - Khaw, K-T

AU - Wareham, N

AU - Allen, N E

AU - Travis, R C

AU - Fedirko, V

AU - Jenab, M

AU - Michaud, D S

AU - Chuang, S-C

AU - Romaguera, D

AU - Bueno-de-Mesquita, H B

AU - Rohrmann, S

PY - 2012/5/22

Y1 - 2012/5/22

N2 - Background:Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce.Methods:We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models.Results:None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI.Conclusion:Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer.

AB - Background:Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce.Methods:We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models.Results:None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI.Conclusion:Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer.

U2 - 10.1038/bjc.2012.172

DO - 10.1038/bjc.2012.172

M3 - Journal article

SN - 0007-0920

VL - 106

SP - 1866

EP - 1874

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort

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