Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis: A multicentre study of 1117 cases

  • Søren Schou Olesen (Ophavsperson)
  • Jakob Lykke Poulsen (Ophavsperson)
  • Srdan Novovic (Bidrager)
  • Camilla Nøjgaard (Ophavsperson)
  • Evangelos Kalaitzakis (Ophavsperson)
  • Nanna M Jensen (Ophavsperson)
  • Trond Engjom (Ophavsperson)
  • Erling Tjora (Ophavsperson)
  • Anne Waage (Ophavsperson)
  • Truls Hauge (Ophavsperson)
  • Stephan L Haas (Ophavsperson)
  • Miroslav Vujasinovic (Ophavsperson)
  • Giedrus Barauskas (Ophavsperson)
  • Aldis Pukitis (Ophavsperson)
  • Imanta Ozola-Zālīte (Bidrager)
  • Alexey Okhlobystin (Ophavsperson)
  • Mikael Parhiala (Ophavsperson)
  • Johanna Laukkarinen (Ophavsperson)
  • Asbjørn Mohr Drewes (Ophavsperson)



BackgroundDiabetes mellitus is a common complication of chronic pancreatitis. It is traditionally considered to develop as a consequence of beta cell loss, but there might be additional factors. Recent studies have highlighted the importance of type 2 diabetes-related risk factors in this context and population-based studies show increased risk of diabetes following acute pancreatitis. The aim of this study was to explore multiple risk factors for diabetes in patients with chronic pancreatitis.MethodsWe conducted a multicentre, cross-sectional study of patients with definitive chronic pancreatitis according to the M-ANNHEIM criteria. We used multivariable logistic regression models to determine risk factors independently associated with diabetes.ResultsThe study included 1117 patients of whom 457 (40.9 %) had diabetes. The mean age was 52.8 ± 14.2 years and 67% were men. On multivariate analysis, parameters indicative of beta cell loss (pancreatic calcification, exocrine insufficiency, pancreatic resection) were confirmed as independent risk factors for diabetes (all p ≤ 0.02). In addition, type 2 diabetes-related risk factors (dyslipidaemia and overweight/obesity) were associated with the presence of diabetes (all p ≤ 0.002). Patients with a history of pancreatic fluid collections (indicative of previous attacks of acute pancreatitis) had a marginally increased risk of diabetes (p = 0.07).ConclusionIn patients with chronic pancreatitis the presence of diabetes is associated with multiple risk factors including type 2 diabetes-related factors. Our observations attest to the understanding of this entity and may have implications for treatment.
Dato for tilgængelighed2020
ForlagSage Journals