• Fredrik Bajers Vej 3B

    DK-9220 Aalborg Øst

    Danmark

Organisationsprofil

Organisationsprofil

Background
Stem cells are becoming an ever more important element in medical therapies. Until recently, stem cells were almost exclusively used to repopulate bone marrow depleted after chemo- and/or radiotherapy. They are now also used in a number of experimental therapies ranging from inborn errors of metabolism, endocrine and cardiovascular disorders to various neurological conditions.

Extensive global research is being done on the potential of human stem cells, and a number of private companies are preparing to enter the market.

The Laboratory for Stem Cell Research has a background in in vitro oxygen tension control of transcription regulation of molecular processes in human tumour cells and is now spearheading the basic and translational research into novel regenerative therapies based on the use of embryonic and somatic stem cells. The laboratory is focused on the development of innovative interdisciplinary approaches to control the fate of stem cells and devise original clinically applicable cell- and tissue-based products.

Main activities
The main research activities of the laboratory are focused on four basic areas:

  1. The role of oxygen in the control of the fate of stem cells
  2. The use of adipose stem cells in the construction of a novel cartilage implant
  3. The use of embryonic stem cells in the treatment of limbal stem cells deficiency
  4. The use of mesenchymal stem cells in the treatment of myocardial failure

The laboratory has recently set up a unique cell culture facility that enables manipulation and continuous growth of the cells in a fully controlled atmosphere. This workstation makes possible investigations on the responses of the embryonic (ESC) and mesenchymal (MSC) stem cells to hypoxic conditions. The molecular mechanisms underlying maintenance of pluripotential state of ESCs or differentiation of MSC into various specific lineages are investigated through specific genes as well as transcriptomic, proteomic, genomic, and miRNA studies.

Regarding the novel approaches to treat the cartilage defects/osteoarthritis, specific forms of blindness, and myocardial infarction/failure, we are exploring the therapeutic potential of both the MSCs and ESCs. We are attempting to translate the basic knowledge regarding the biology and molecular biology of the stem cells into advanced tissue engineering and cell-based procedures applicable in routine medical practice. To that end, the laboratory is collaborating with several prestigious clinics in Denmark and abroad.

Future perspectives
Our long-term goal is to use stem cells for ex vivo production of biological spare parts.

Fingeraftryk Fingeraftrykket er baseret på teksten fra de videnskabelige dokumenter, der er relateret til de tilknyttede personer. Baseret på dette oprettes et indeks af vægtede ord, der definerer de vigtigste emner i forskningsenheden

Stem Cells Medicin og biovidenskab
Stem cells Kemiske forbindelser
Spermatozoa Medicin og biovidenskab
Tissue Engineering Medicin og biovidenskab
Tissue Kemiske forbindelser
Biomechanical Phenomena Medicin og biovidenskab
Diamond Medicin og biovidenskab
Boron Medicin og biovidenskab

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Projekter 2002 2016

Cancer stem cells

Duroux, M., Pilgaard, L. & Zachar, V.

01/01/2011 → …

Projekter: ProjektForskning

Reconstruction of ocular surface based on the somatic stem cells

Zachar, V., Søndergaard, C., Yang, S. & Emmersen, J.

01/01/2011 → …

Projekter: ProjektForskning

Differentiation and engineering of smooth muscle

Emmersen, J., Wang, F., Zachar, V. & Pennisi, P.

01/01/2011 → …

Projekter: ProjektForskning

Publikationer 2002 2019

1 Downloads (Pure)

From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering

Abbas, T. O., Yalcin, H. C. & Pennisi, C. P., 10 apr. 2019, I : International Journal of Molecular Sciences . 20, 7

Publikation: Bidrag til tidsskriftReview (oversigtsartikel)Forskningpeer review

Åben adgang
Fil
tissue engineering
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds
26 Downloads (Pure)

A modified monomeric red fluorescent protein reporter for assessing CRISPR activity

Knudsen, C. H., ásgrímsdóttir, E. S., Rahimi, K., Gill, K. P., Frandsen, S., Buchholdt, S. H., Chen, M., Kjems, J., Febbraro, F. & Denham, M., 15 maj 2018, I : Frontiers in Cell and Developmental Biology. 6, 10 s., 54.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Clustered Regularly Interspaced Short Palindromic Repeats
Terminal Repeat Sequences
Inverted Repeat Sequences
Transfection
Nucleotides

Bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine

Rahmati, M., Pennisi, C. P., Mobasheri, A. & Mozafari, M., 2018, Cell Biology and Translational Medicine: Stem Cells, Bio-materials and Tissue Engineering. Turksen, K. (red.). Springer, s. 73-89 17 s. (Advances in Experimental Medicine and Biology, Bind 1107).

Publikation: Bidrag til bog/antologi/rapport/konference proceedingBidrag til bog/antologiForskningpeer review

Regenerative Medicine
Tissue Engineering
Biocompatible Materials
Stem Cells
Stem Cell Niche

Aktiviteter 2015 2017

  • 3 Foredrag og præsentationer i privat eller offentlig virksomhed
  • 2 Konferenceoplæg
  • 1 Medlemskab af bedømmelsesudvalg

Advances in semen analysis techniques and functional tests

Hiva Alipour (Oplægsholder)
31 maj 2017

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

Dansk Fertilitetsselskabs Årsmøde 2016

Hiva Alipour (Oplægsholder)
13 mar. 2016

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Improved sperm kinematics in consecutive sperm samples

Hiva Alipour (Foredragsholder)
1 maj 2017

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

Presse/medie

Tre forskertalenter fik legater

Simone Riis Porsborg

21/02/2019

1 element af mediedækning

Presse/medie

Legat til talentfuld diabetesforsker

Simone Riis Porsborg

03/12/2018

1 element af mediedækning

Presse/medie