Projekter pr. år
Organisationsprofil
Organisationsprofil
Head of research group: Torben Moos
Who we are?
The group encompasses these members: Prof. Torben Moos, Assoc. Prof. Ove Wiborg, Assoc. Prof. Louiza Bohn Thomsen, Asst. Prof. Annette Burkhart, Asst. Prof. Maj Schneider Thomsen, Postdoc Lisa Juul Routhe, PhD Student Eva Hede Olsen, PhD Student Steinunn Sara Helgudottir, PhD Student Charlotte L.M. Rasmussen, PhD Student Amanda Clement, Technician Merete Fredsgaard and Technician Hanne Krone Nielsen.
Our research – what we do?
We focus on understanding the biology of the brain’s vasculature both in health and pathology. We also focus on the restraints of the brain’s vasculature for drug delivery. We develop strategies for delivery of drugs to the brain using, e.g. gene therapy, therapeutic nanoparticles and antibodies intended for treatment of patients with brain diseases like Alzheimer’s disease, Niemann-Picks disease and brain cancer. Our experimental models are primarily based on rodent in vivo models and in vitro primary cell culture models.
How does our research contribute to societal health challenges?
We contribute with basic knowledge about the anatomy and physiology of the brain vasculature, which is useful for increasing the knowledge about the development and progression of brain diseases like Alzheimer’s disease, hemorrhage and brain cancer. We also contribute to optimizing existing treatment and developing new treatment strategies for multiple types of brain diseases.
Who are our key collaborators?
We collaborate with leading scientists from University of Copenhagen, Aarhus University, University of Southern Denmark, The Technical University of Denmark (DTU), Uppsala University, University of Hamburg and other research groups at Aalborg University. Furthermore, we collaborate with leading national and international pharmaceutical companies.
Fingerprint
Samarbejde i de sidste fem år
Profiler
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Bartosz Laczek
- Det Sundhedsvidenskabelige Fakultet - Ph.d.-stipendiat
- Institut for Medicin og Sundhedsteknologi - Ph.d.-stipendiat
- Neurobiological Research and Drug Delivery - Ph.d.-stipendiat
Person: VIP
Projekter
- 2 Afsluttet
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Targeteret terapi i den hypoksiske og inflammerede blod-hjerne barriere
Helgudottir, S. S., Schneider Thomsen, M., Moos, T. & Johnsen, K. B.
Aase og Ejnar Danielsens fond , Kong Christian den Tiendes Fond
01/03/2019 → 01/03/2021
Projekter: Projekt › Forskning
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Epigenetisk regulering af ferroportin i den neurovaskulære enhed
Helgudottir, S. S., Lichota, J., Routhe, L. J., Moos, T., Jønsson, K., Larsen, A. B. & Pedersen, I. S.
01/12/2017 → 01/11/2019
Projekter: Projekt › Forskning
Publikationer
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Behavioural characteristics and sex differences of a treatment-resistant depression model: Chronic mild stress in the Wistar-Kyoto rat
Loizeau, V., Durieux, L., Mendoza, J., Wiborg, O., Barbelivien, A. & Lecourtier, L., 4 feb. 2024, I: Behavioural Brain Research. 457, 114712.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
1 Citationer (Scopus) -
Metabolic effect of the retina in a murine model of AD
Bermudez, M. Y. G., Vohra, R., Freude, K. K., Thomsen, M. S., Aldana, B. I. & Kolko, M., jan. 2024, I: Acta Ophthalmologica. 102, S279Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review
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A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus
Rasmussen, C. L. M., Hede, E., Routhe, L. J., Körbelin, J., Helgudottir, S. S., Thomsen, L. B., Schwaninger, M., Burkhart, A. & Moos, T., jan. 2023, I: Journal of Neurochemistry. 164, 1, s. 6-28 23 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil4 Citationer (Scopus)24 Downloads (Pure)
Forskningsdatasæt
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Additional file 1 of Intravenous iron isomaltoside versus oral iron supplementation for treatment of iron deficiency in pregnancy: protocol for a randomised, comparative, open-label trial
Pinborg, A. (Ophavsperson), Moos, T. (Ophavsperson), Holm, C. (Ophavsperson), Hansen, R. (Ophavsperson), Thomsen, L. L. (Ophavsperson) & Markova, V. (Ophavsperson), Figshare, 2020
DOI: 10.6084/m9.figshare.12864674.v1, https://doi.org/10.6084%2Fm9.figshare.12864674.v1
Datasæt
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Intravenous iron isomaltoside versus oral iron supplementation for treatment of iron deficiency in pregnancy: protocol for a randomised, comparative, open-label trial
Markova, V. (Ophavsperson), Hansen, R. (Ophavsperson), Thomsen, L. L. (Ophavsperson), Pinborg, A. (Ophavsperson), Moos, T. (Ophavsperson) & Holm, C. (Ophavsperson), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5102231.v1, https://springernature.figshare.com/collections/Intravenous_iron_isomaltoside_versus_oral_iron_supplementation_for_treatment_of_iron_deficiency_in_pregnancy_protocol_for_a_randomised_comparative_open-label_trial/5102231/1
Datasæt
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Intravenous iron isomaltoside versus oral iron supplementation for treatment of iron deficiency in pregnancy: protocol for a randomised, comparative, open-label trial
Markova, V. (Ophavsperson), Hansen, R. (Ophavsperson), Thomsen, L. L. (Ophavsperson), Pinborg, A. (Ophavsperson), Moos, T. (Ophavsperson) & Holm, C. (Ophavsperson), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5102231, https://springernature.figshare.com/collections/Intravenous_iron_isomaltoside_versus_oral_iron_supplementation_for_treatment_of_iron_deficiency_in_pregnancy_protocol_for_a_randomised_comparative_open-label_trial/5102231
Datasæt
Presse/medier
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Unge kan få varige mén af nikotinposer
10/04/2024 → 11/04/2024
3 elementer af Mediedækning
Presse/medie
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Nyt studie: Mikroplast kan komme ind i hjernen på mus - gælder det også for mennesker?
17/12/2021
1 element af Mediedækning
Presse/medie