Maternal ultra-processed food consumption during pregnancy and inflammatory bowel disease risk in the child - a cohort study

Projektdetaljer

Beskrivelse

Background: Despite the rising prevalence of inflammatory bowel disease (IBD) during the last decades, its causes are yet not understood fully. Prenatal exposures may contribute to IBD development, however, human studies on gestational diet are lacking. Furthermore, high ultra-processed food (UPF) consumption during pregnancy is suggested to contribute to disease in offspring. Therefore, this study will to explore the association between maternal UPF intake during pregnancy and offspring’s IBD risk during childhood.
Methods: The study will include mother-child dyads from the Danish National Birth Cohort (DNBC), a prospective cohort study from Denmark with pregnant women and their offspring. A semi-quantitative food frequency questionnaire assessed maternal diet in gestational week 25, and the Nova classification system was applied to maternal food intake to determine UPF consumption. IBD in offspring was identified from birth until 18 years of age in the National Patient Registry and linked with data from the DNBC using participants’ CPR-number. Offspring’s hazard ratio for IBD and its subtypes associated with maternal UPF intake (% of total energy intake) will be estimated using Cox proportional hazards model.
Results: Pending.
StatusIgangværende
Effektiv start/slut dato01/06/202301/12/2024

Samarbejdspartnere

  • Statens Serum Institut

FN's verdensmål

I 2015 blev FN-landene enige om 17 verdensmål til at bekæmpe fattigdom, beskytte planeten og sikre velstand for alle. Dette projekt bidrager til følgende verdensmål:

  • Verdensmål 3 - Sundhed og trivsel

Emneord

  • inflammatory bowel diseases
  • mother-child relations
  • humans
  • pregnancy
  • prospective studies
  • prenatal exposure delayed effects
  • birth cohort
  • food, processed
  • pregnant women
  • diet
  • cohort studies
  • Denmark
  • registries
  • food frequency questionnaire

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