Stem cells and probiotics for chronic wound healing in an diabetic animal models

Skin is the largest organ of the body that forms a protective physical barrier against pathogens and foreign particles. Loss of skin integrity because of a cut or break in the skin results in microbial colonization in the wound. Cutaneous wound healing is critical to replace damaged tissue with a healthy one.
Diabetes is a significant health problem in developing countries and the incidence of the disease increases dramatically every year. The current treatments are to control the levels of hyperglycemia and diabetic complications, and in between one of these complications is wound healing problem. Diabetes normally increases wound complications and makes it resistant for the treatment, which delays or stops the healing, which makes finding an effective strategy to enhance the healing process a necessity.
The present study aimed to detect the effect of stem cells (adipose-derived stem cells) and strain of probiotics (Lactobacillus rhamnosus PB01 (Bifodan A/S, Denmark)), alone or in combination on a wound model in Rats.