DNA is a fascinating soft material that naturally expresses two of the three main features required from molecular nanoelectronic components, namely recognition and specific structuring (sequence, length). The third additional property that is needed in order to implement DNA-derivatives for electrical device applications is conductivity, still quite disputable in native-DNA. Within this project our consortium will study novel DNA-based nanowires (incl. DNA triplexes, quadruplexes as well DNA-polymer hybrids), evolved from modifications of the native double helix, that show encouraging conductivity signals while preserving the structuring and recognition qualities. We plan to proceed to the more ambitious goal of realizing DNA-based nanodevices on the ground of the disclosed nanowires, by maturing to a full control over the molecular structure and electric response. e propose the design, realization, and testing of DNA-based devices that can serve as building blocks for self-organized molecular nanoelectronics.